Role of Radiotherapy in Managing cSCC

Radiation therapy serves as both a definitive and adjuvant option in cutaneous squamous cell carcinoma (cSCC) management. Panelists note that it is particularly valuable for patients with positive margins, perineural invasion, or inoperable disease due to medical or anatomic limitations.

The conversation covers dose planning, balancing efficacy with skin toxicity, and using radiotherapy postoperatively to reduce recurrence. Advances in image-guided and hypofractionated techniques have expanded its role, particularly for elderly or frail patients.

They conclude that radiation therapy remains a key pillar of multidisciplinary cSCC care, often enabling durable control where surgery alone may be insufficient.