Recognizing High-Risk cSCC Patients for Early Biopsy

Patients with chronic immunosuppression, organ transplants, or prior radiation exposure are at elevated risk for aggressive cutaneous squamous cell carcinoma (cSCC). Panelists stress the need for early biopsy when lesions demonstrate rapid growth, ulceration, or pain.

The discussion highlights how delayed diagnosis often correlates with deeper invasion and worse prognosis. Regular surveillance and patient education can promote early detection, especially among those with multiple or recurrent skin lesions.

They agree that vigilance, coupled with a low threshold for biopsy in at-risk populations, remains essential to intercept disease early and improve outcomes through prompt multidisciplinary evaluation.