Approach to Evaluating Suspected cSCC

Panelists outline how the initial evaluation of a suspicious cutaneous lesion begins with a thorough history and focused examination. Clinical clues such as lesion growth rate, ulceration, induration, or fixation to deeper structures help determine suspicion for squamous cell carcinoma (SCC). Dermoscopy, photography, and tissue biopsy remain the cornerstones of confirmation, while pathology guides risk assessment.

They emphasize that early and accurate diagnosis is crucial for preventing disease progression. Superficial biopsies risk underestimating tumor depth, so deep shave or punch biopsies are often preferred. The panel also stresses documentation of lesion size, margins, and perineural symptoms to inform downstream management.

Overall, the panel agrees that an evidence-based, structured evaluation—combining clinical observation with pathology and imaging when indicated—ensures an accurate diagnosis and lays the foundation for an individualized treatment plan.