Defining Primary Treatment Options in cSCC

Panelists reaffirm surgery as the cornerstone of cutaneous squamous cell carcinoma (cSCC) treatment, providing high local control rates and pathologic confirmation of complete excision. Depending on tumor risk and location, options include standard excision or margin-controlled techniques.

Adjuvant radiation therapy is considered for incomplete margins, perineural invasion, or extensive disease not amenable to resection. For unresectable cases, systemic therapy is emerging as a viable alternative.

Overall, treatment planning is increasingly risk-adapted, with multidisciplinary coordination ensuring that each patient receives the least invasive yet most effective therapy for durable control.