First AD

Second AD

Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors

What are some ongoing Phase II/III trials in this space?

Phase II Vinblastine +/- Bevacizumab in chemotherapy naïve pLGG (

Phase III ACNS1831: Selumetinib vs carboplatin/vincristine in NF1 pLGG (

Phase III ACNS1833: Selumetinib vs carboplatin/vincristine in non-V600E and non-NF1 pLGG (

Clinical

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Insights

Insights is an expert interview video series of leading oncologists that provides in-depth reports and feature segments profiling leaders in a range of oncology disciplines, including breast cancer, lung cancer, gastrointestinal cancers, genitourinary cancers, gynecologic cancers, and hematologic malignancies. Most episodes feature 2 clinicians discussing the latest oncology advances in clinical practice. 

Video Series

Novel Breakthroughs in Management of Pediatric Low-Grade Glioma (pLGG)

The panel reviews ongoing clinical trials for non-BRAF V600E pediatric low-grade gliomas (pLGG), specifically highlighting the Phase III ACNS1831 and Phase III ACNS1833 studies, discussing their objectives, designs, and potential implications for future treatment strategies.

Overview of pLGG presentation and categorization