Novel Breakthroughs in Management of Pediatric Low-Grade Glioma (pLGG) - Episode 12

Clinical scenario 1 - BRAFKIAA-1549 fusion

The panel examines a specific patient case, offering detailed insights into their decision-making process and treatment approaches for patients with pediatric low-grade gliomas (pLGG).

  1. Of the possible options, what treatment approach would you select for this patient?
  2. What key clinical or patient-specific factors informed this choice?
  3. Please consider and discuss alternate scenarios:
  4. What if this patient had received frontline chemotherapy (instead of selumetinib) and then progressed? How would this impact your treatment decision?
  5. What if the patient was currently on a MEKi, would you switch?