Novel Breakthroughs in Management of Pediatric Low-Grade Glioma (pLGG) - Episode 11

Clinical Trials to Increase Treatment Options in the Progressive Setting

August 23, 2024

The panel reviews ongoing clinical trials aimed at expanding treatment options for progressive pediatric low-grade gliomas (pLGG), with a specific focus on the PNOC021, PBTC-055, and NF111 studies, discussing their objectives, design features, and potential impact on future treatment strategies.

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EP. 1: Overview of pLGG presentation and categorization

EP. 2: Molecular Characterization of pLGG

EP. 3: Less Common Molecular Alterations in pLGG and Testing Recommendations

EP. 4: Standard of care for frontline treatment of non-V600E-specific pLGG tumors

EP. 5: Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors

EP. 6: Current Treatment of Patients with NF1 pLGG

EP. 7: Standard of Care Pptions Specific for Frontline Treatment of BRAF V600E-Mutated pLGG

EP. 8: Treatment Considerations for Progressive pLGG

EP. 9: Radiation and Targeted Therapies for Progressive pLGG

EP. 10: The Role of Tovorafenib in Treatment of Progressive pLGG

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EP. 11: Clinical Trials to Increase Treatment Options in the Progressive Setting

EP. 12: Clinical scenario 1 - BRAFKIAA-1549 fusion

EP. 13: Alternatives and Considerations for Clinical Scenario 1

EP. 14: Clinical Scenario 2 - BRAFV600E

EP. 15: Potential Adverse Events With Targeted Therapies

EP. 16: Clinical Insights: Looking Forward for pLGG

Please briefly describe the various treatment options that might be considered in R/R pLGG
- Clinical trial enrollment
  - PNOC021: Phase I Trametinib + Everolimus in NF1 LGG/HGG (NCT04485559)
  - NF111: Phase II Poly-ICLC in NF1 LGG (NCT04544007)
  - PBTC-055: Phase I/II trial of Dabrafenib, Trametinib, and Hydroxychloroquine (HCQ) for BRAF V600E-mutant or Trametinib and HCQ for BRAF fusion/duplication or NF1 (NCT04201457)