OncLive SOSS

Novel Breakthroughs in Management of Pediatric Low-Grade Glioma (pLGG) - Episode 16

Clinical Insights: Looking Forward for pLGG

September 6, 2024

Jason Fangusaro, MD

The leaders in the pediatric low-grade glioma (pLGG) field offer their concluding insights and perspectives on the future of pLGG management.

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EP. 1: Overview of pLGG presentation and categorization

EP. 2: Molecular Characterization of pLGG

EP. 3: Less Common Molecular Alterations in pLGG and Testing Recommendations

EP. 4: Standard of care for frontline treatment of non-V600E-specific pLGG tumors

EP. 5: Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors

EP. 6: Current Treatment of Patients with NF1 pLGG

EP. 7: Standard of Care Pptions Specific for Frontline Treatment of BRAF V600E-Mutated pLGG

EP. 8: Treatment Considerations for Progressive pLGG

EP. 9: Radiation and Targeted Therapies for Progressive pLGG

EP. 10: The Role of Tovorafenib in Treatment of Progressive pLGG

EP. 11: Clinical Trials to Increase Treatment Options in the Progressive Setting

EP. 12: Clinical scenario 1 - BRAFKIAA-1549 fusion

EP. 13: Alternatives and Considerations for Clinical Scenario 1

EP. 14: Clinical Scenario 2 - BRAFV600E

EP. 15: Potential Adverse Events With Targeted Therapies

EP. 16: Clinical Insights: Looking Forward for pLGG

How do you approach long-term treatment planning and sequencing decisions as patients progress?
1. How do you incorporate radiotherapy into treatment sequencing?
2. When might treatment switching be appropriate?

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