Advancements in the Management of Gynecological Cancers: ESMO 2024 - Episode 7

Antibody-Drug Conjugates in Ovarian Cancer: Emerging Data and Treatment Integration

October 21, 2024

Angeles Alvarez Secord, MD, MHSc , Dana M. Chase, MD, FACOG, Bhavana Pothuri, MD, Premal H. Thaker, MD, MS, Thomas C. Krivak, MD

Panelists discuss recent data on various antibody-drug conjugates (ADCs) in ovarian cancer, including mirvetuximab soravtansine from trials like FORWARD II, MIRASOL, and PICCOLO; luveltamab tazevibulin and rinatabart sesutecan from STRO-002-GM1 and REFRαME-O1; and raludotatug deruxtecan from REJOICE-Ovarian01, highlighting the evolving role of these agents in the treatment landscape for ovarian cancer.

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EP. 1: Approaching Biomarker Testing and Frontline Maintenance Therapy for Advanced Ovarian Cancer

EP. 2: Key Findings from the PRIMA Trial: Niraparib in 1L Maintenance for Advanced Ovarian Cancer

EP. 3: Duration of PARP Inhibitor Maintenance Therapy for Ovarian Cancer

EP. 4: Emerging Combinations in Maintenance Therapy for Ovarian Cancer

EP. 5: Optimizing Ovarian Cancer Care: PARP Resistance, Management of Oligoprogression, and Adverse Event Mitigation

EP. 6: Use of Trastuzumab Deruxtecan in Ovarian Cancer

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EP. 7: Antibody-Drug Conjugates in Ovarian Cancer: Emerging Data and Treatment Integration

EP. 8: Navigating Treatment Strategies for Advanced Cervical Cancer: Localized Therapy, KEYNOTE-A18 Trial Data, and Frontline Approaches

EP. 9: Integrating Tisotumab Vedotin into Ovarian Cancer Therapy

EP. 10: Biomarker Testing in Advanced Endometrial Cancer: Approach, Key Markers, and Impact on Treatment Decisions

EP. 11: Managing Recurrent Endometrial Cancer: Treatment Strategies and RUBY Trial Insights

EP. 12: Durvalumab in Endometrial Cancer: DUO-E Trial Updates

EP. 13: Innovative Combination Strategies for Endometrial Cancer: Updates from LEAP and KEYNOTE-B21 Trials

EP. 14: T-DXd in Advanced Endometrial Cancer

EP. 15: Emerging ADCs in Advanced Endometrial Cancer: Anti-TROP2 and Anti-FR Agents

Video content above is prompted by the following:

Briefly comment on recent data surrounding other antibody-drug conjugates in ovarian cancer and discuss the evolving role of these agents in the treatment landscape.
Mirvetuximab soravtansine (anti-FR)
FORWARD II; MIRASOL; PICCOLO
Luveltamab tazevibulin (anti-FR), rinatabart sesutecan (Rina-S)
STRO-002-GM1; REFRαME-O1
Rina-S
Raludotatug deruxtecan (R-DXd, anti-CDH6)
REJOICE-Ovarian01