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SPEARHEAD-1: Overview of Study Design, Key Efficacy, and Safety

Video content above is prompted by the following:

Briefly review the pivotal SPEARHEAD-1 trial that led to afami-cel’s approval.

Please review study design, key efficacy and safety (

Please explain the role of targeting MAGE-A4.

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Advancing Synovial Sarcoma Care: Exploring Innovations in Targeted Therapies

Panelists discuss how afamitresgene autoleucel (afami-cel) demonstrated meaningful clinical activity in SPEARHEAD-1, with manageable cytokine release syndrome as the main safety concern.