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Advancing Synovial Sarcoma Care: Exploring Innovations in Targeted Therapies - Episode 11

Approaches to First-Line Treatment for Synovial Sarcoma

A panelist discusses how the standard first-line approach for synovial sarcoma typically involves anthracycline-based chemotherapy (often doxorubicin with ifosfamide) while considering factors such as patient age, performance status, and tumor burden to determine the specific regimen intensity and duration.

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  • Chapters
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    EP. 1: Brief Overview of Synovial Sarcoma: What It Is, Clinical Presentation and Diagnosis
    EP. 2: Addressing Unmet Needs in Synovial Sarcoma and Recent FDA Approval of Afami-cel
    EP. 3: SPEARHEAD-1: Overview of Study Design, Key Efficacy, and Safety
    EP. 4: Afami-cel Approval and Its Potential Influence on the Adoption of TCR Therapies
    EP. 5: Key Differences in T-Cell Response Therapy vs CAR T Therapy
    EP. 6: Optimal Timing for Introducing Afami-Cel Therapy in the Treatment Journey
    EP. 7: Sequencing Strategies of Afami-Cel With Chemotherapy and Targeted Therapies
    EP. 8: Addressing Potential Barriers to the Adoption of Afami-Cel Therapy
    EP. 9: Best Practices for HLA and MAGE-A4 Testing
    EP. 10: Diagnositc Feasibility: Liquid Biopsy vs Tissue Biopsy for Diagnostic Testing
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    EP. 11: Approaches to First-Line Treatment for Synovial Sarcoma
    EP. 12: Potential Impact of Afami-Cel Therapy on the Standard of Care for R/R Cases
    EP. 13: Comparing Postinfusion Challenges in TCR Therapy and Standard-of-Care Regimens
    EP. 14: Logistical Considerations for Delivering TCR Therapy to Patients
    EP. 15: Comparing Afami-Cel Outcomes With Chemotherapy and Other Treatment Options
    EP. 16: Future Perspectives on TCR Therapies for Sarcomas and Other Solid Tumors

    Video content above is prompted by the following:

    What is your typical approach to first-line treatment for synovial sarcoma?

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