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Advancing Synovial Sarcoma Care: Exploring Innovations in Targeted Therapies - Episode 14

Logistical Considerations for Delivering TCR Therapy to Patients

A panelist discusses how the logistical challenges of delivering T-cell receptor (TCR) therapy include coordinating lymphodepletion timing, managing the multiweek manufacturing process, ensuring proper handling and chain of custody of cellular products, and requiring specialized treatment centers with cell therapy expertise and infrastructure.

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  • Chapters
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    EP. 1: Brief Overview of Synovial Sarcoma: What It Is, Clinical Presentation and Diagnosis
    EP. 2: Addressing Unmet Needs in Synovial Sarcoma and Recent FDA Approval of Afami-cel
    EP. 3: SPEARHEAD-1: Overview of Study Design, Key Efficacy, and Safety
    EP. 4: Afami-cel Approval and Its Potential Influence on the Adoption of TCR Therapies
    EP. 5: Key Differences in T-Cell Response Therapy vs CAR T Therapy
    EP. 6: Optimal Timing for Introducing Afami-Cel Therapy in the Treatment Journey
    EP. 7: Sequencing Strategies of Afami-Cel With Chemotherapy and Targeted Therapies
    EP. 8: Addressing Potential Barriers to the Adoption of Afami-Cel Therapy
    EP. 9: Best Practices for HLA and MAGE-A4 Testing
    EP. 10: Diagnositc Feasibility: Liquid Biopsy vs Tissue Biopsy for Diagnostic Testing
    EP. 11: Approaches to First-Line Treatment for Synovial Sarcoma
    EP. 12: Potential Impact of Afami-Cel Therapy on the Standard of Care for R/R Cases
    EP. 13: Comparing Postinfusion Challenges in TCR Therapy and Standard-of-Care Regimens
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    EP. 14: Logistical Considerations for Delivering TCR Therapy to Patients
    EP. 15: Comparing Afami-Cel Outcomes With Chemotherapy and Other Treatment Options
    EP. 16: Future Perspectives on TCR Therapies for Sarcomas and Other Solid Tumors

    Video content above is prompted by the following:

    What are the logistical challenges of delivering TCR therapy to patients?

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