ASCO 2024: Updates in the Treatment of Advanced Renal Cell Carcinoma - Episode 2

Dr Wulff-Burchfield Reviews CheckMate 214 and CheckMate 9ER

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The panelists examine the latest findings from the CheckMate 214 trial, which assessed the combination of nivolumab and ipilimumab (nivo + ipi) as a first-line treatment for advanced renal cell carcinoma, focusing on efficacy, safety, and quality of life outcomes.

  1. Please briefly discuss the recent data from the CheckMate 214 trial evaluating nivo + ipi for 1L treatment of advanced RCC.
    1. 8-year follow-up and subgroup analyses – please comment on OS, DOR, PFS, TFS, and safety (Tannir et al., ASCO GU 2024 Abstract 363)
    2. What insights do the recent HRQoL data provide? (Cella et al., Oncologist Jan 2024)
  2. Please comment on the role of doublet regimens in the 1L setting for advanced RCC and their recent data updates.
    1. CheckMate 9ER nivo + cabo 
    2. 55-month follow up (Bourlon et al., ASCO GU 2024 Abstract 362)
    3. HRQoL (Bedke et al., ASCO GU 2024 Abstract 384)
    4. Partitioned 4-year OS (Mantia et al., ASCO 2024 Abstract 4507)