ESMO 2024: Treatment of uHCC - Episode 6

Discussion and Summary

October 25, 2024

Richard Finn, MD, Olatunji Alese, MD, Daneng Li, MD, Anthony El-Khoueiry, MD, Masatoshi Kudo, MD, PhD, Steven Chan, MD

Panelists discuss the findings from the LEAP-012 study, which explores the efficacy of transarterial chemoembolization combined with lenvatinib and pembrolizumab in patients with Child-Pugh class A disease and intermediate-stage hepatocellular carcinoma.

EP. 1: Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

EP. 2: Treatment Decisions Based on BLCL Stage

EP. 3: Current Treatment in First Line – IO + TKI or IO + IO

EP. 4: Use of monotherapy (IO or TKI) or localized treatment in First Line

EP. 5: EMERALD-1 Study Results

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EP. 6: Discussion and Summary

EP. 7: LEAP-012 Study Results

EP. 8: Discussion of LEAP-012 and EMERALD-1 Study Results and Appropriate Sequencing

Video content above is prompted by the following:

Transarterial chemoembolization plus or minus lenvatinib plus pembrolizumab for intermediate-stage hepatocellular carcinoma (Llovet, Proffered Paper, Presidential Symposium I: Practice Changing Trials, ESMO 2024, Barcelona Spain, LBA3) Can’t add until the morning of the presentation on Monday, September 16 .