Daneng Li, MD

Daneng Li, MD, is an associate professor in the Department of Medical Oncology & Therapeutics Research and co-director of the Neuroendocrine Tumor Program at City of Hope.

Articles

CABINET Trial: Efficacy and Safety Results

July 9th 2025

Panelists discuss how the CABINET trial enrolled nearly 300 patients with well-differentiated neuroendocrine tumors (NETs) (mostly grade 1-2) who were heavily pretreated, demonstrating cabozantinib’s superiority over placebo with over 8 months progression-free survival vs 3 months, with manageable toxicity and effective dose reduction strategies.

Cabozantinib Approval for NET Treatment

July 9th 2025

Panelists discuss how cabozantinib approval helps fill treatment gaps for patients who have exhausted standard therapies like somatostatin analogs, peptide receptor radionuclide therapy (PRRT), and everolimus, providing a new option for healthy patients seeking additional treatment lines in this indolent but progressive disease.

Treatment Landscape in Neuroendocrine Tumors

July 2nd 2025

Panelists discuss how the treatment landscape has been shaped by landmark trials including the RADIANT studies (everolimus for pancreatic and other neuroendocrine tumors [NETs]), sunitinib studies for pancreatic NETs, the NETTER-1 trial (lutetium-177 dotatate), and capecitabine/temozolomide data, providing multiple targeted therapy options that have dramatically improved patient outcomes.

Neuroendocrine Tumors: Second-Line Treatment Options

July 2nd 2025

Panelists discuss how peptide receptor radionuclide therapy (PRRT) has traditionally been the go-to second-line treatment after somatostatin analog progression, though there’s hesitancy due to it being a “one-shot deal,” and growing interest in moving PRRT to earlier lines for patients with high disease burden.

Treatment Decision-Making for Neuroendocrine Tumors

June 25th 2025

Panelists discuss how treatment decisions after progression on first-line somatostatin analog therapy must consider disease location, symptom burden, quality of life impact, and patient comorbidities when choosing between options like peptide receptor radionuclide therapy (PRRT), targeted therapies (mTOR inhibitors, tyrosine kinase inhibitors), or local-regional treatments.

Treatment Options for Patients With Neuroendocrine Tumors

June 25th 2025

Panelists discuss how initial treatment recommendations require a comprehensive framework considering tumor site of origin, symptom burden, disease grade and distribution, somatostatin receptor status, and patient factors, with somatostatin analogs typically serving as first-line therapy for appropriate patients based on data from the PROMID and CLARINET trials.

Overview of Neuroendocrine Tumors

June 18th 2025

Panelists discuss how neuroendocrine tumors (NETs) are defined as cancers of neuroendocrine cells that can develop almost anywhere in the body, are classified as functional or nonfunctional, and are categorized as well-differentiated (graded by Ki-67 index) or poorly differentiated neuroendocrine carcinomas with very aggressive biology.

Evolving Understanding of Neuroendocrine Tumors

June 18th 2025

Panelists discuss how the understanding and treatment of neuroendocrine tumors (NETs) has evolved dramatically over the past 3 to 4 decades, with incidence rising to nearly 200,000 in the population and survival extending from just a few years to 8 to 10-plus years through advances from single-agent somatostatin analogs to targeted therapies.

Dr Li on the Casdozokitug/Atezolizumab/Bevacizumab in Unresectable HCC

February 28th 2025

Daneng Li, MD, discusses a trial evaluating casdozokitug plus atezolizumab and bevacizumab in unresectable, locally advanced or metastatic HCC.

Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs

November 29th 2024

Panelists discuss how ongoing trials and investigational agents, including the Checkmate 9DW study, could significantly influence future treatment approaches for unresectable hepatocellular carcinoma .

CheckMate 9DW Study Results and Use of Ipiimumab/Nivolumab in First- and Second-Line Treatment

November 29th 2024

Panelists discuss key updates from the 2024 American Society of Clinical Oncology Annual Meeting and the European Society for Medical Oncology Congress 2024 regarding treatments for unresectable hepatocellular carcinoma (uHCC), including insights from the CheckMmate 9DW study on the use of nivolumab and ipilimumab, and their implications for sequencing and combination therapies in various lines of treatment.

Importance of Real-World Data in Supporting Treatment Options

November 29th 2024

Panelists discuss the insights from real-world data on the effectiveness of cabozantinib, regorafenib, and ramucirumab in second-line treatment for unresectable hepatocellular carcinoma, highlighting the differences between strict eligibility criteria and more flexible modified criteria in patient selection.

Discussion of RESORCE Trial

November 22nd 2024

Panelists discuss the data from the RESORCE trial, highlighting the efficacy of regorafenib in previously treated hepatocellular carcinoma, including primary trial results and insights on time to progression based on prior sorafenib treatment.

Real-World Treatment Data from the Phase 4 STELLAR Trial

November 22nd 2024

Panelists discuss the findings from the STELLAR trial, a phase 4 observational study presented at the European Society for Medical Oncology Congress 2024, which compares the efficacy of lenvatinib and sorafenib as first-line treatments for patients with advanced or unresectable hepatocellular carcinoma.

Discussion of CELESTIAL Trial and Second-Line Treatment in Japan

November 15th 2024

Panelists discuss the CELESTIAL trial findings and their implications for second-line treatment strategies in Japan for patients with previously treated hepatocellular carcinoma.

CELESTIAL Sub-Group Discussion

November 15th 2024

Panelists discuss the subgroup analyses from the CELESTIAL trial, focusing on treatment outcomes for specific patient populations with previously treated hepatocellular carcinoma.

Choosing Second-Line Therapies: Considering First Line Therapy Received

November 8th 2024

Panelists discuss how to determine appropriate second-line and subsequent therapies for unresectable hepatocellular carcinoma after frontline treatment, emphasizing patient-specific factors and alternatives to clinical trial enrollment.

ImBRAVE 050 Study Results and Discussion Around Who is a High-Risk Patient

November 8th 2024

Panelists discuss findings from the IMmbrave050 trial comparing atezolizumab plus bevacizumab to active surveillance in patients with high-risk hepatocellular carcinoma patients, highlighting the significance of follow-up for those at risk of recurrence post- curative treatment.

EMERALD-1 Study Results

October 25th 2024

Panelists discuss the findings from the EMERALD-1 trial on durvalumab with or without bevacizumab combined with transarterial chemoembolization TACE for first-line treatment of unresectable hepatocellular carcinomaHCC, examining its implications on progression-free survival, safety, and outcomes based on baseline tumor burden.

Discussion and Summary

October 25th 2024

Panelists discuss the findings from the LEAP-012 study, which explores the efficacy of transarterial chemoembolization combined with lenvatinib and pembrolizumab in patients with Child-Pugh class A disease and intermediate-stage hepatocellular carcinoma.