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ESMO 2024: Treatment of uHCC - Episode 10

Choosing Second-Line Therapies: Considering First Line Therapy Received

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Panelists discuss how to determine appropriate second-line and subsequent therapies for unresectable hepatocellular carcinoma after frontline treatment, emphasizing patient-specific factors and alternatives to clinical trial enrollment.

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    EP. 1: Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)
    EP. 2: Treatment Decisions Based on BLCL Stage
    EP. 3: Current Treatment in First Line – IO + TKI or IO + IO
    EP. 4: Use of monotherapy (IO or TKI) or localized treatment in First Line
    EP. 5: EMERALD-1 Study Results
    EP. 6: Discussion and Summary
    EP. 7: LEAP-012 Study Results
    EP. 8: Discussion of LEAP-012 and EMERALD-1 Study Results and Appropriate Sequencing
    EP. 9: ImBRAVE 050 Study Results and Discussion Around Who is a High-Risk Patient
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    EP. 10: Choosing Second-Line Therapies: Considering First Line Therapy Received
    EP. 11: Discussion of CELESTIAL Trial and Second-Line Treatment in Japan
    EP. 12: CELESTIAL Sub-Group Discussion
    EP. 13: Discussion of RESORCE Trial
    EP. 14: Real-World Treatment Data from the Phase 4 STELLAR Trial
    EP. 15: Importance of Real-World Data in Supporting Treatment Options
    EP. 16: CheckMate 9DW Study Results and Use of Ipiimumab/Nivolumab in First- and Second-Line Treatment
    EP. 17: Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs

    Video content above is prompted by the following:

    Dr El-Khoueiry/Dr Kudo: After frontline therapy in unresectable hepatocellular carcinomauHCC, how do you determine the appropriate second- line and beyond therapy?
    • What patient-specific factors do you consider?
    • Other than clinical trial enrollment, what would you consider for second-line2L treatment?

    Related Content:

    ESMO 2024: Treatment of uHCC
    Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs
    CheckMate 9DW Study Results and Use of Ipiimumab/Nivolumab in First- and Second-Line Treatment
    Importance of Real-World Data in Supporting Treatment Options
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