ESMO 2024: Treatment of uHCC - Episode 10

Choosing Second-Line Therapies: Considering First Line Therapy Received

November 8, 2024

Richard Finn, MD, Olatunji Alese, MD, Daneng Li, MD, Anthony El-Khoueiry, MD, Masatoshi Kudo, MD, PhD, Steven Chan, MD

Panelists discuss how to determine appropriate second-line and subsequent therapies for unresectable hepatocellular carcinoma after frontline treatment, emphasizing patient-specific factors and alternatives to clinical trial enrollment.

EP. 1: Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

EP. 2: Treatment Decisions Based on BLCL Stage

EP. 3: Current Treatment in First Line – IO + TKI or IO + IO

EP. 4: Use of monotherapy (IO or TKI) or localized treatment in First Line

EP. 5: EMERALD-1 Study Results

EP. 6: Discussion and Summary

EP. 7: LEAP-012 Study Results

EP. 8: Discussion of LEAP-012 and EMERALD-1 Study Results and Appropriate Sequencing

EP. 9: ImBRAVE 050 Study Results and Discussion Around Who is a High-Risk Patient

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EP. 10: Choosing Second-Line Therapies: Considering First Line Therapy Received

EP. 11: Discussion of CELESTIAL Trial and Second-Line Treatment in Japan

EP. 12: CELESTIAL Sub-Group Discussion

EP. 13: Discussion of RESORCE Trial

EP. 14: Real-World Treatment Data from the Phase 4 STELLAR Trial

Video content above is prompted by the following:

Dr El-Khoueiry/Dr Kudo: After frontline therapy in unresectable hepatocellular carcinomauHCC, how do you determine the appropriate second- line and beyond therapy?
• What patient-specific factors do you consider?
• Other than clinical trial enrollment, what would you consider for second-line2L treatment?