Expert Perspectives & Insights into CAR T-cell Therapy in Relapsed / Refractory Acute Lymphoblastic Leukemia - Episode 18

Strategies and Resources for Overcoming Barriers to CAR T-Cell Therapy

August 23, 2024

Elias Jabbour, MD, Evandro D. Bezerra, MD, Lori Muffly, MD, Jae H. Park, MD, Gregory W. Roloff, MD

Acute lymphoblastic leukemia specialists explore resources and strategies to address the logistical hurdles of CAR-T therapy implementation, while also examining patient support programs designed to enhance treatment accessibility and adherence.

EP. 1: Overview of CAR T-cell Therapies in R/R B-cell ALL

EP. 2: CAR T-cell Therapy: Mechanisms of Actions of Brexucabtagene Autoleucel and Obecabtagene Autoleucel

EP. 3: Considerations for Dosing and Lymphodepletion with CAR T-cell Therapy in R/R ALL

EP. 4: Expert Perspectives on CAR T-Cell Therapy Logistics: Collection to Treatment

EP. 5: Overview of Available Treatment Options in R/R B-cell ALL

EP. 6: Navigating CAR T-cell Therapy in R/R ALL: Expert Perspectives

EP. 7: Expert Insights on ZUMA-3 Data Updates: 4-Year Follow-up and Real World Data

EP. 8: Treatment Considerations and Patient Selection for CAR T-cell Therapy in R/R ALL

EP. 9: Expert Perspectives on Bridging Therapy Strategies Prior to CAR T-cell Therapy

EP. 10: Sequencing Strategies with CAR T-cell Therapy in Patients with or without Prior Blinatumomab Treatment

EP. 11: Translating Data Updates from FELIX and ZUMA-3 to the Clinical Practice Setting

EP. 12: Expert Perspectives on the Potential Impact of Obe-cel on the Treatment Landscape for R/R ALL

EP. 13: Treatment Approaches with Consolidation and Maintenance Post CAR T-cell Therapy

EP. 14: Future Perspectives on CAR T-cell Therapy in R/R B-cell ALL

EP. 15: Frequency, Correlation with Clinical Outcomes, and Risk Factors for Severe CRS and ICANS in CAR T-cell Therapy

EP. 16: Expert Perspectives in Monitoring and Management Strategies for CRS, ICANS, and Other Long-Term Toxicities Associated with CAR T-cell Therapy

EP. 17: Logistical and Access Challenges with CAR T-cell Therapy in R/R ALL

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EP. 18: Strategies and Resources for Overcoming Barriers to CAR T-Cell Therapy

EP. 19: Role of Multidisciplinary Team & Logistics of CAR T-cell Therapy Administration in the Inpatient or Outpatient Setting

EP. 20: Key Takeaways and Clinical Pearls in the Treatment of R/R ALL

Video content above is prompted by the following:

What are some resources and/or strategies to help support and solve these logistical challenges?
- Please comment on different CAR-T patient support programs (lodging, support resources etc.)
At your institution, are patients who are eligible for CAR-T cell Therapy discussed at a multidisciplinary meeting to discuss these challenges?
Are Apheresis or cell laboratory members, social workers, case managers, nurses, pharmacy involved? If so, what are each discipline roles?