Elias Jabbour, MD; Evandro D. Bezerra, MD; Lori Muffly, MD; Jae H. Park, MD, and Gregory W. Roloff, MD,review the role of CAR T-cell therapy\ for relapsed/refractory acute lymphoblastic leukemia, address adverse event management and supportive care, and highlight significant updates presented at the American Society of Clinical Oncology and European Hematology Association 2024 conferences.