Experts discuss key factors influencing the decision between immunotherapy (IO)/IO and various IO/tyrosine kinase inhibitor (TKI) combinations in advanced renal cell carcinoma (RCC) treatment, including patient characteristics, risk stratification, PD-L1 status, and other clinical features, while also exploring the patient experience with IO-TKI regimens, strategies for managing adverse effects, and the approach to hepatotoxicity management.
Video Player is loading.
Current Time 0:00
/
Duration 0:00
Loaded: 0%
Stream Type LIVE
Remaining Time -0:00
1x
2x
1.75x
1.5x
1.25x
1x, selected
0.75x
0.5x
Chapters
descriptions off, selected
captions settings, opens captions settings dialog
captions off, selected
This is a modal window.
Beginning of dialog window. Escape will cancel and close the window.
End of dialog window.
This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.
When you’re evaluating treatment options for your advanced RCC patients today, what key factors drive your decision between the IO/IO approach with ipilimumab/nivolumab vs the various IO/TKI combinations like pembrolizumab/lenvatinib, pembrolizumab/axitinib, nivolumab/cabozantinib, or avelumab/axitinib? How do you weigh patient characteristics, risk stratification, PD-L1 status, and other clinical features in this decision?
Dr Barata asks Dr Beckermann:Briefly discuss your perspective on the patient experience for patients undergoing IO/TKI regimens and explore strategies for their mitigation and management.
Comment on how patterns of hepatoxicity differ across trials and discuss your general approach to management.