Optimizing IO Sequencing: Strategies for Integration Into Treatment Algorithms in Advanced EC

Summary for Physicians:

To better integrate IO sequencing into treatment algorithms, a key step is ensuring that clear, evidence-based guidelines are established to define when and how IO therapies should be used. This involves refining patient selection criteria, such as identifying those with specific biomarkers (eg, microsatellite instability, tumor mutational burden) or molecular profiles that predict better responses to IO therapies. Additionally, integrating IO sequencing into multidisciplinary treatment discussions and decision-making can help ensure that it is appropriately incorporated into a patient’s overall treatment plan. Standardizing sequencing strategies—such as deciding the optimal timing for IO therapy relative to other treatments—will also help streamline its use. Furthermore, ongoing education for clinicians about evolving IO sequencing data and clinical trial results will facilitate more informed, consistent decision-making. Collaborative efforts with other specialists, such as pathologists and genetic counselors, can also improve the effective integration of IO sequencing into clinical practice.