Exploring Percutaneous Hepatic Perfusion in Metastatic Uveal Melanoma

Andrea Forschner, MD, and Shaheer Ahmad Khan, DO, discuss the rationale behind percutaneous hepatic perfusion (PHP) as a regional therapy designed to control liver-dominant disease in patients with metastatic uveal melanoma. They outline how PHP delivers high-dose chemotherapy directly to the liver with systemic exposure mitigation, offering a potential therapeutic advantage for selected patients. They also comment on procedural considerations and evolving clinical data that support its use.