Updates in the Treatment of HR+/HER2- Breast Cancer - Episode 12

Exploring Data of PI3K/AKT/mTOR Inhibitors in HER2– mBC

February 18, 2025

Panelists discuss the use of alpelisib in light of the inavolisib approval and the impact of capivasertib (CAPItello-291 trial) on the treatment landscape and sequencing options for HR+/HER2– metastatic breast cancer (mBC).

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EP. 1: Diagnosis and Risk Stratification for Early-Stage HR+/HER2- Breast Cancer

EP. 2: CDK4/6 Inhibitors for HR+/HER2- Early Breast Cancer

EP. 3: Current Practices for Targeted Therapies and Molecular Testing for HR+/HER2- Metastatic Breast Cancer

EP. 4: Exploring 1L and 2L CDK4/6 Inhibitors + Endocrine Therapies

EP. 5: Clinical Perspectives: Use of CDK4/6i After CDK4/6i

EP. 6: The Current Treatment Landscape of Oral SERDs in Metastatic Breast Cancer

EP. 7: Clinical Findings of Elacestrant, an Oral SERD for ER+/HER2– Metastatic Breast Cancer

EP. 8: Emerging Data of Additional SERDs in Metastatic Breast Cancer

EP. 9: CDK4/6 Inhibitors Plus Novel Agents for ER+/HER2–Advanced or mBC

EP. 10: Toxicities and Treatment Selection of Endocrine-Based Therapies in HR+/HER2– Breast Cancer

EP. 11: Genotype-Directed Therapies for HR+/HER2– Advanced Breast Cancer

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EP. 12: Exploring Data of PI3K/AKT/mTOR Inhibitors in HER2– mBC

EP. 13: Clinical Developments of Antibody-Drug Conjugates (ADCs) in HR+/HER2– mBC

EP. 14: ADCs: Recent Data of Dato-DXd from TROPION-Breast01

EP. 15: Impact of ADC Toxicities and Clinical Decision-Making for mBC

EP. 16: Continued Advances and Treatment Sequencing for HR+/HER2– Breast Cancer

Video content above is prompted by the following:

Dr. Bardia to Dr. Gradishar: Alpelisib – When and how will alpelisib be used, particularly considering the inavolisib approval?

Dr. Bardia to Dr. Gradishar: Capivasertib – How has the approval of capivasertib (CAPItello-291) shifted the treatment landscape and sequencing options for patients with HR+/HER2–- mBC?