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Emerging Data and Treatment Trends in Paroxysmal Nocturnal Hemoglobinuria After EHA 2025 - Episode 4

Data for Iptacopan in PNH After Switching Anti-C5 Therapy: The APPULSE-PNH Trial

July 16, 2025

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, David Dingli, MD, PhD

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, and David Dingli, MD, PhD, on data for iptacopan in PNH after switching anti-C5 therapy.

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EP. 1: Reviewing Current Standards in Paroxysmal Nocturnal Hemoglobinuria

EP. 2: Role of C5 Inhibitors in the Management of Paroxysmal Nocturnal Hemoglobinuria

EP. 3: Implications of the FDA Approval of Iptacopan for PNH

EP. 4: Data for Iptacopan in PNH After Switching Anti-C5 Therapy: The APPULSE-PNH Trial

EP. 5: Factors for Selecting Iptacopan in C5 Inhibitor–Naive and –Exposed PNH

EP. 6: Implications of APPULSE-PNH Data for Iptacopan in PNH

EP. 7: Addressing Further Unmet Needs in PNH

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