Lung Cancer | Specialty

The OncLive Lung Cancer condition center page is a comprehensive resource for clinical news and expert insights on non–small cell lung cancer, small cell lung cancer, mesothelioma, and more. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in lung cancer.

Dr Chiappori on the Integration of Ensartinib Into the NSCLC Treatment Arsenal

March 11th 2025

Alberto Chiappori, MD, discusses the selection between frontline treatment options, including ensartinib, in ALK-positive non–small cell lung cancer.

Health Canada Approves Amivantamab/Lazertinib Combo for EGFR+ Advanced NSCLC

March 11th 2025

Amivantamab plus lazertinib was approved in Canada for first-line EGFR-mutated locally advanced or metastatic non–small cell lung cancer.

Dato-DXd Plus Durvalumab ± Carboplatin Delivers Antitumor Activity in Advanced NSCLC

March 10th 2025

Frontline treatment with datopotamab deruxtecan plus durvalumab with/without carboplatin proved active in advanced NSCLC without actionable alterations.

China’s NMPA Approves Sacituzumab Tirumotecan for Pretreated EGFR+ Advanced NSCLC

March 10th 2025

The Chinese NMPA has approved sacituzumab tirumotecan for EGFR-mutant advanced NSCLC following progression on an EGFR TKI and chemotherapy.

China’s NMPA Accepts MAA for Foritinib in ALK+ Advanced NSCLC

March 10th 2025

China’s NMPA has accepted an MAA seeking the approval of foritinib for ALK-positive advanced non–small cell lung cancer.

Five Under 5: Top Oncology Videos for the Week of 3/2

March 9th 2025

The top 5 OncLive videos of the week cover insights in TGCT, NSCLC, TNBC, AML, and MDS.

Personalizing Adjuvant Targeted Therapy in Early-Stage NSCLC

March 7th 2025

Panelists discuss how, in clinical practice, ADAURA (osimertinib) and ALINA (alectinib) are integrated based on EGFR/ALK status, stage, and recurrence risk. Adjuvant therapy duration is typically 3 years. Circulating tumor DNA (ctDNA), minimal residual disease (MRD) from ADAURA (ASCO 2024, Abs 8005) may refine treatment decisions by detecting MRD.

Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

March 7th 2025

Panelists discuss how recent data from KEYNOTE-671, AEGEAN, and CheckMate 77T reinforce neoadjuvant therapy’s efficacy in early-stage non–small cell lung cancer (NSCLC), showing consistent survival benefits. In contrast, adjuvant data remain conflicting, limiting its role. Neoadjuvant therapy should be prioritized, with adjuvant therapy reserved for select high-risk patients.

Closing Thoughts and Clinical Pearls: Future Perspectives in NSCLC

March 6th 2025

The expert discussion concludes with reflections on the rapid advancements in the treatment of locally advanced lung cancer, emphasizing the importance of personalized therapy, multidisciplinary collaboration, and continued progress in improving patient outcomes.

Key Takeaways From the PACIFIC-2 Trial: The Role of Concurrent Immunotherapy With CRT

March 6th 2025

The discussion explores promising future directions for managing locally advanced disease, focusing on combination immunotherapy approaches and the ongoing trials investigating their efficacy, as well as the potential role of combining chemotherapy (CRT) with immunotherapy in treatment regimens.

Expert Insights on the LAURA Trial: Osimertinib After CRT in Unresectable Stage III EGFRm NSCLC as a New Standard of Care

March 6th 2025

The discussion focuses on the LAURA trial, which demonstrated that osimertinib significantly improved progression-free survival in patients with EGFR-mutated (EGFRm) locally advanced non–small cell lung cancer (NSCLC) after chemoradiotherapy (CRT), establishing it as a new standard of care with manageable safety concerns.

A 76-Year-Old Woman With Locally Advanced Unresectable Stage III EGFRm NSCLC

March 6th 2025

A 76-year-old woman with EGFR exon 19–positive adenocarcinoma and N3 disease undergoes chemoradiotherapy followed by osimertinib after a multidisciplinary evaluation and biomarker testing.

Exploring the Role of SBRT in Unresectable NSCLC: Patient Selection and Trial Insights

March 6th 2025

This segment explores the use of stereotactic body radiation therapy (SBRT) for treating small peripheral lesions in patients with lymph node–positive cancer, compared with conventional intensity-modulated radiation therapy. It discusses the potential advantages of SBRT in reducing treatment duration, its theoretical biological effects, and ongoing studies like the LU008 phase 3 trial.

Assessment and Management Strategies for Pneumonitis in Durvalumab Consolidation Post Chemoradiotherapy

March 6th 2025

This video discusses the clinical considerations around pneumonitis in patients undergoing chemoradiation and immunotherapy, including how to distinguish between radiation-induced and immune-related pneumonitis, and the importance of consulting specialists to avoid prematurely discontinuing treatment like durvalumab.

Consolidation Durvalumab in Unresectable Stage III NSCLC: Management Strategies and the Role of ctDNA

March 6th 2025

This video discusses evolving treatment paradigms for locally advanced lung cancer, highlighting the impact of trials like PACIFIC on the role of chemoradiotherapy and consolidation therapy with durvalumab, the potential integration of circulating tumor DNA (ctDNA) for personalized treatment decisions, and the implications for both surgical and nonsurgical patient populations.

Tailoring Chemoradiotherapy Approaches in Unresectable Stage III NSCLC

March 6th 2025

This segment transitions to discussing the management of unresectable non–small cell lung cancer (NSCLC), focusing on the distinctions between concurrent and sequential chemoradiation. It highlights patient selection, treatment tolerability, the role of advanced radiation technologies, and considerations for minimizing adverse effects while ensuring optimal outcomes.

Ensartinib Looks to Find a Place in ALK+ NSCLC Paradigm Alongside Approved TKIs

March 5th 2025

Alberto Chiappori, MD, details how to select between ensartinib and approved ALK TKIs for NSCLC, as well as considerations with ensartinib’s FDA approval.

Tumor-Agnostic Approvals of T-DXd and Repotrectinib Carry the Field Forward

March 5th 2025

Clinicians parse through the impacts of tumor-agnostic FDA approvals, examining T-DXd and repotrectinib's 2024 approvals in particular.

Dr Zhou on Frontline Ivonescimab vs Pembrolizumab in PD-L1+ Advanced NSCLC

March 3rd 2025

Caicun Zhou, MD, PhD, discusses data for ivonescimab vs pembrolizumab as first-line treatment for patients with PD-L1–positive advanced NSCLC.

CHMP Recommends Perioperative Durvalumab Regimen in Resectable NSCLC

March 3rd 2025

The CHMP has recommended the approval of perioperative durvalumab plus neoadjuvant chemotherapy for patients with resectable NSCLC.