Precision Medicine in Oncology® | Specialty

The OncLive Precision Medicine in Oncology® condition center page is a comprehensive resource for clinical news and expert insights on precision-focused approaches in patients with cancer, with gene-targeted tyrosine kinase inhibitors and antibody-drug conjugates, checkpoint inhibitors, tumor-infiltrating lymphocyte therapy, and other tailored treatments. This page features news articles, interviews in written and video format, and podcasts that focus on updates and ongoing research with personalized therapies across solid and hematologic tumors.

Biomarker Predicts Survival Benefit in Advanced Kidney Cancer Treated With TORC1 Inhibitor

September 26th 2012

Pretreatment serum lactate dehydrogenase is a prognostic factor in poor-risk patients with renal cell carcinoma and also a predictive factor for a survival benefit from treatment with temsirolimus.

ENCODE Decodes DNA

September 25th 2012

A consortium of over 442 global investigators at 32 institutions recently reported results in over 30 publications of a decade of work from the Encyclopedia of DNA Elements project.

Panels of Molecular Markers Improve Diagnosis of Thyroid Cancer

September 24th 2012

The application of molecular markers is already significantly improving the diagnosis of thyroid cancer and broader application could help prevent unnecessary surgeries to confirm the diagnosis.

BRAF Mutational Status in Papillary Microcarcinoma: Diagnostic and Prognostic Potential

September 24th 2012

Four histopathologic features of papillary microcarcinoma help predict how aggressive the tumor will be and subsequently how aggressive treatment must be to prevent its spread.

Disease Stabilization Now Possible in Metastatic MTC With Targeted Therapies

September 21st 2012

The availability of molecular agents that target oncogenic signaling pathways now offers the possibility of achieving disease stabilization in a proportion of patients with metastatic medullary thyroid cancer.

Beyond Tumor Type: HER2 Link in Leukemia Setting Shows Molecular Profiling Potential

September 21st 2012

Trastuzumab has demonstrated activity in patients with B-cell adult acute lymphocytic leukemia who exhibit evidence of upregulation of the HER2 receptor.

Targeted Therapy Combination Slows NSCLC

September 14th 2012

Patients with refractory non-small cell lung cancer had a statistically significant improvement in PFS when treated with targeted therapy duo versus a single agent.

Mutation Confers Anti-EGFR Resistance

September 14th 2012

A common mutation in NSCLC confers resistance to tyrosine kinase inhibitors and worsens survival, creating a need for an alternative approach to treating the subgroup of patients with the mutation.

Dr. Gandara on Patient Selection for Molecular Testing

September 12th 2012

Dr. David Gandara from the UC Davis Comprehensive Cancer Center on Patient Selection for Molecular Testing in Lung Cancer

Trials in Progress Poster Session

September 10th 2012

The Trials in Progress Poster Session at the ASCO Annual Meeting, now in its third year, is intended to stimulate discussion in the oncology community about ongoing clinical trials and to promote collaboration.

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine: Leading the Way in Cancer Genomics

September 7th 2012

Siteman patients have access to more than 250 therapeutic clinical trials, and Siteman-affiliated scientists and physicians hold more than $165 million in annual cancer research and related training grants.

Dr. Peter Choyke Discusses Molecular Imaging Research

September 6th 2012

Dr. Peter Choyke, from the National Cancer Institute, Molecular Imaging Program, Discusses Current Molecular Imaging Research.

Vismodegib Effective Against Skin Cancer in Patients With Basal-Cell Nevus Syndrome

August 31st 2012

The oral hedgehog pathway inhibitor vismodegib is effective for both the prevention and treatment of basal-cell carcinoma in patients with the rare disorder known as basal-cell nevus syndrome.

Dr. Scagliotti on Targeted Therapies and Chemotherapy

August 31st 2012

Dr. Giorgio Scagliotti, from the University of Turin, San Luigi Hospital, on Combining Targeted Therapies With Chemotherapy for Lung Cancer Patients.

Dr. Sekulic on the Hedgehog Pathway Inhibitor Vismodegib

August 30th 2012

Dr. Aleksandar Sekulic, from the Mayo Clinic in Arizona, on the Hedgehog Pathway Inhibitor Vismodegib for Basal Cell Carcinoma.

Targeted PD-1 Therapy Offers Opportunity to Sequence Agents

August 30th 2012

Drugs that target the programmed death-1 pathway hold considerable promise for the treatment of patients with melanoma, particularly in integrating the agents into the sequence of therapy.

Targeted Therapies May Have a Role in Urothelial Cancer

August 28th 2012

Pazopanib has demonstrated activity in a majority of patients with refractory urothelial cancer, providing the first evidence that targeted therapies might have a role in the disease.

5 ALK-Related Questions for D. Ross Camidge, MD, PhD and Fredika M. Robertson, PhD

August 27th 2012

Two leading researchers discuss the role of the ALK signaling pathway and development into new ALK-targeted anticancer therapies.

ALK Inhibitors: Moving Rapidly From Discovery to Clinical Approval and Beyond

August 27th 2012

There has been stunning progress as preclinical findings of the ALK gene in patients with lung cancer were rapidly translated into the availability of an FDA-approved therapeutic ALK inhibitor, crizotinib.

Dr. Ribas on MAPK Inhibition With Dabrafenib and Trametinib

August 23rd 2012

Dr. Antoni Ribas, from UCLA Jonsson Comprehensive Cancer Center, on the Benefits of MAPK Inhibition With Dabrafenib and Trametinib