Lauren M. Green

Articles

Can Aspirin Avert Lethal Prostate Cancer? Long-term Study Suggests a Possible Role

January 4th 2016

Aspirin’s benefits may now extend to reducing the risk of deadly prostate cancer, according to the results of an observational study which found that previously undiagnosed men who took regular aspirin had a 24% lower risk of developing a lethal form of the disease.

Tamoxifen or Anastrozole? Patient Reports Can Help Decide

December 11th 2015

Patient reports of their experiences with taking either tamoxifen or anastrozole can help clinicians decide which one to recommend to individual women, new research has found.

Survival Better With Breast-Conserving Therapy Versus Mastectomy in Early-Stage Cancers

December 10th 2015

Women who opt for breast-conserving therapy and radiation to treat their early-stage breast cancer are about 20% more likely to be alive after 10 years compared with their counterparts who had mastectomy.

Denosumab Demonstrates Survival Benefit in Postmenopausal Women

December 9th 2015

A follow-up analysis of the benefits of adding denosumab to aromatase inhibitor therapy has found that the agent not only helps to prevent fractures, it reduces the risk of recurrence and death in postmenopausal women with HR-positive breast cancer.

Optimizing Precision Medicine Approaches in Glioblastoma

November 22nd 2015

The deployment of precision medicine to develop safe and effective therapies to treat malignant brain tumors is an effort that poses both opportunities and challenges.

Early Research Signals Potential for CAR T-Cell Therapy in EGFRvIII-Positive GBM

November 22nd 2015

A pilot study of the efficacy of CAR T-cell therapy in patients with EGFRvIII-positive glioblastoma multiforme (GBM) has generated encouraging findings.

Testing Checkpoint Inhibitors in Brain Cancer Requires Careful AE Management

November 20th 2015

As immunotherapy begins to be studied across central nervous system tumors it becomes increasingly important for practitioners to understanding the unique adverse event profiles associated with these agents.

In Pursuit of Less Toxic Treatments for HPV+ Oropharyngeal Cancers

November 5th 2015

While the prognosis remains good for individuals with HPV-positive oropharyngeal cancers, the incidence of these cancers continues to rise, and researchers are currently seeking less intense treatment options that are equally effective but not as toxic for patients.

Individualizing Care for Patients With Polycythemia Vera

November 4th 2015

The landscape for the diagnosis and treatment of polycythemia vera (PV) is changing, and that's good news for patients and practitioners who can look to improvements ahead.

Adjuvant Radiation Therapy Extends Survival in TNBC

October 13th 2015

Adjuvant radiation therapy was shown to improve overall survival and disease-specific survival following lumpectomy for elderly women with early stage triple-negative breast cancer.

Survival Trends Higher With Necitumumab in EGFR FISH-Positive Squamous NSCLC

September 9th 2015

Survival for patients with metastatic squamous non–small cell lung cancer whose tumors were positive for EGFR copy number as determined by FISH analysis tended to be better when the EGFR antibody necitumumab was added to their conventional chemotherapy.

Failure to Follow Weight-Based Chemo Guidelines Lowers Survival in Ovarian Cancer

July 23rd 2015

Women with ovarian cancer who experienced an average dose reduction of ≤85% had a 35% higher mortality risk than those who received normal dosing.

Disparities Persist Despite Rise in Breast-Conserving Surgery Rate

July 7th 2015

Despite the overall rate increase in breast-conserving therapy among women with early-stage breast cancer, economic and geographic factors have left some patients behind.

Off-Label Access to Targeted Therapies Offered Through ASCO's First-Ever Clinical Trial

June 1st 2015

Physicians will now have a new option for some patients who have run out of them, but whose tumors have a genomic variation matching a drug target that is FDA-approved for a different cancer.

Preventive Neck Lymph Node Surgery Should Become Standard of Care in Early Oral Cancer

May 31st 2015

Elective neck dissection performed at the same time patients have surgery for early-stage, node-negative, oral squamous cell cancer significantly improved overall survival and reduced the risk of death and recurrence when compared with a watchful waiting approach.

Anastrozole Shows Preventive Advantages Over Tamoxifen After DCIS

May 31st 2015

The first study to compare the efficacy and safety of tamoxifen versus anastrozole in women treated for ductal carcinoma in situ suggests that anastrozole may be the better choice for preventing the escalation of DCIS into invasive cancer.

Obinutuzumab Doubles PFS in Refractory Indolent Non-Hodgkin Lymphoma

May 30th 2015

Patients with relapsed indolent non-Hodgkin lymphoma experienced a doubling of progression-free survival when treated with a combination of the anti-CD20 agent obinutuzumab and bendamustine.

Pembrolizumab Demonstrates "Remarkable Efficacy" in Advanced HNSCC

May 29th 2015

In a multisite study offering the largest experience to date of how immunotherapy can be deployed in patients with head and neck cancer, the anti-PD-1 antibody pembrolizumab produced broad and durable responses in patients with advanced disease.

Changing the Screening Paradigm: Study Supports Follow-up Ultrasounds for Women With Dense Breasts

May 23rd 2015

To assess the impact of additional screening, Jean M. Weigert, MD, FACR, head of breast imaging for the Hospital of Central Connecticut, conducted a retrospective chart review to see how well it worked in detecting cancers in women with dense breasts during the first 4 years of implementation statewide.

Nicotinamide Reduces New Skin Cancers in Those at High Risk

May 13th 2015

For those with a history of non-melanoma skin cancer, reducing their risk of recurrence can be as simple as taking the vitamin B3 pill nicotinamide.

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