Operationalizing Screening for Non-Small Cell Lung Cancer: An International Discussion - Episode 3

Why Fast Biomarker Results are Critical for NSCLC Patients

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Experts discuss the critical importance of turnaround time for comprehensive biomarker testing in NSCLC. They compare systems, with one center performing in-house NGS testing and reporting key results like EGFR and ALK via rapid FISH/PCR in 3-5 days, allowing for immediate treatment decisions without waiting for the full NGS report.

The conversation highlights that while centralized labs can achieve a 5-day turnaround time, shipping samples adds delay. Both agree that experienced thoracic centers are essential, not just for speed but for constant quality improvement, adapting to new biomarkers, and integrating advanced techniques like liquid biopsy. They stress that a fast, coordinated diagnostic pathway—from biopsy by trained pulmonologists to immediate test ordering—is crucial. Delays negatively impact patient prognosis, making efficient, center-based workflows a key factor in improving lung cancer outcomes.