Video content above is prompted by the following: Dr. Conlin to Dr. O’Shaughnessy: Looking ahead, how do you see the treatment landscape evolving? What impact might the SERENA-6 trial have on sequencing practices (Turner et al. Future Oncology 2023)? What mechanisms of resistance to PI3K/AKT pathway inhibitors or oral SERDs do you anticipate? What unmet needs remain to be addressed?