Real-World Data in ALK+ NSCLC

Panelists highlight that real-world data provide valuable insights into treatment effectiveness across broader patient populations than those typically represented in clinical trials. They discuss how differences in comorbidities, adherence, and health care access affect outcomes and underscore the need to contextualize trial results accordingly.

Real-world studies confirm that the efficacy and tolerability observed in trials translate well to routine clinical settings. However, they also reveal challenges in maintaining adherence and managing toxicity outside controlled environments.

The segment concludes that leveraging both clinical and real-world evidence ensures more accurate expectations of treatment benefit, helping clinicians individualize therapy and monitor outcomes in diverse practice settings.