Treatment Advancements in Newly Diagnosed and Relapsed/Refractory in Multiple Myeloma - Episode 3
Management Approaches and Unmet Needs in Transplant-Ineligible NDMM
Panelists discuss how treating newly diagnosed, transplant-ineligible multiple myeloma patients requires a nuanced approach that accounts for comorbidities, age, and functional status to optimize induction therapy.
Addressing the Needs of Transplant-Ineligible Older Patients
Managing newly diagnosed multiple myeloma in transplant-ineligible patients, often older adults with comorbidities, presents unique challenges. These patients exhibit heterogeneity not only in tumor biology but also in functional status, necessitating individualized treatment strategies.
The therapeutic goal remains to achieve the deepest response with the least toxicity. This requires balancing efficacy and tolerability by tailoring regimens based on frailty assessments and comorbid conditions. Recent data supports the use of modified quadruplets even in older patients under select conditions.
Approaches that integrate advanced therapeutics in less intensive formats or abbreviated durations are under evaluation to better suit this population. These strategies aim to maximize benefit without compromising safety in those unable to undergo stem cell transplant.
Related Content:
