SERDs in Focus: Optimizing Treatment Strategies in HR+ HER2- Breast Cancer - Episode 4
Imlunestrant Clinical Data: Insights From the EMBER and EMBER-3 Trials
Dr. Clifton and Dr. Gandhi review the EMBER trial program, discussing study designs, key findings from phase 1b and EMBER-3 trials of imlunestrant-based combinations, and insights into efficacy, safety, and subgroup outcomes in estrogen receptor–positive/HER2-negative (ER+/HER2–) advanced breast cancer (ABC).
Video content above is prompted by the following:
- Please provide an overview of the EMBER trial study design, arms, and high-level takeaways from the following:
- EMBER phase 1b: imlunestrant plus or minus everolimus or alpelisib
- EMBER phase 1b: imlunestrant plus abemaciclib plus or minus aromatase inhibitor
- Please provide some background on the EMBER-3 trial investigating imlunestrant plus or minus abemaciclib in ER+/HER2– ABC pretreated with endocrine therapy plus or minus CDK4/6 inhibitor.
- Please provide an overview of major efficacy and safety end points from EMBER-3 as well as subgroup data from the trial.
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