First AD

Second AD

Exploring Dato-DXd Combinations as First-Line Therapy for Advanced NSCLC 

Please discuss the rationale, study design, and key endpoints for the AVANZAR (

) trial evaluating Dato-DXd + durvalumab and carboplatin for 1L treatment of patients with advanced NSCLC without actionable mutations.

What is the rationale for this treatment approach?

What data do you anticipate and how may findings impact the current/future treatment landscape?

In which patients would this treatment strategy most appropriate/beneficial?

Clinical

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Lung Cancer

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OncLive Peer Exchange® 

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Video Series

Targeting NSCLC with Precision: Evaluation of the Emerging Role of Antibody-Drug Conjugates  

Peer Exchange

Julia Rotow, MD, explores the rationale, study design, and primary endpoints of the AVANZAR trial, which investigated the combination of datopotamab deruxtecan (Dato-DXd), durvalumab, and carboplatin as a first-line treatment for patients with advanced non-small cell lung cancer lacking actionable mutations, and discusses the patient population most likely to benefit from this drug combination. 