Jedd D. Wolchok, MD, PhD, chief, Melanoma and Immunotherapeutics Service, Department of Medicine and Ludwig Center at Memorial Sloan Kettering Cancer Center, discusses the safety profile in the CheckMate-067 trial, which examined nivolumab (Opdivo) combined with ipilimumab (Yervoy) in treatment-naïve patients with advanced melanoma.

It is important to emphasize to patients that stopping treatment is not necessarily bad, says Wolchok. A "more is better" mindset is not necessarily the case when it comes to immunotherapy.

The data from CheckMate-067 showed that patients who had to stop treatment due to toxicity from the combination therapy actually achieved a significantly higher response rate of 68%. Thus, it is not clear that stopping treatment is bad for patients, and it may in fact be an indicator of better outcomes, explains Wolchok.

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Immuno-Oncology

Jedd D. Wolchok, MD, PhD, chief, Melanoma and Immunotherapeutics Service, Department of Medicine and Ludwig Center at Memorial Sloan Kettering Cancer Center, discusses the safety profile in the CheckMate-067 trial, which examined nivolumab combined with ipilimumab in treatment-naïve patients with advanced melanoma.

Dr. Wolchok on the Safety Profile in CheckMate-067 in Melanoma