EHA 2024: Updates in the Treatment of CLL - Episode 13

Dr Parrondo shares Approach to Managing BTKi Treatment-Related Afib

August 12, 2024

Catherine C. Coombs, MD, Matthew S. Davids, MD, MMSc, Richardo D. Parrondo, MD , Nicole Lamanna, MD, Alexey V. Danilov, MD, PhD

An oncology specialist outlines their general approach to managing treatment-related atrial fibrillation in patients receiving BTK inhibitor therapy, incorporating insights from recent clinical data to inform their management strategies.

EP. 1: Introducing the Expert Panel on CLL Treatment Updates Live at EHA 2024

EP. 2: Testing Practices and Role of High-risk Features to Decision Making in Newly Diagnosed CLL

EP. 3: Frontline BTKi Selection

EP. 4: Dr Parrondo’s Frontline CLL Treatment Approach for Pre-existing HTN and Afib

EP. 5: Dr Lamanna Reviews Study Data for 1L Doublet Therapy or Triplet Therapy

EP. 6: Dr Danilov Reviews EHA 2024 Data on the Role of 1L Triplet Therapy in CLL

EP. 7: EHA 2024 Review of Ongoing Trials Evaluating BCL2i/BTKi Combination Approaches

EP. 8: Navigating Treatment Approaches for R/R CLL

EP. 9: How Experts View MAIC Data That was Presented at EHA 2024

EP. 10: BTKi Intolerance in Real-world Practice & Management Strategy

EP. 11: Applying EHA 2024 Data to Switching and Sequencing Treatments for CLL & Impact of Toxicities

EP. 12: Approach to Hypertension Management With BTKi Treatment

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EP. 13: Dr Parrondo shares Approach to Managing BTKi Treatment-Related Afib

EP. 14: Navigating BTKi Resistance in CLL with Findings from ELEVATE-RR and ALPINE Studies: Sequencing Approach and Potential Role for Testing

EP. 15: Experts Review Pirtobrutinib Clinical Data and Share its Utilization in Practice

EP. 16: TRANSCEND CLL 004 Data Review and its Impact on Future Treatment Practices

EP. 17: EHA 2024 Updated Data on BTKi Degraders as Emerging Novel Agents in R/R CLL

EP. 18: Dr Parrando Reviews EHA 2024 Data on BTKi Degrader, BGB-16673

EP. 19: Dr Lamanna Shares Perspectives on EHA 2024 Data for the 2G BCL2 Inhibitors in R/R CLL

EP. 20: Review of Data from EHA 2024 of Emerging Novel Bispecific Antibodies

EP. 21: Clinical Pearls and Impacts to Practice from EHA 2024

Dr Parrondo:What is your general approach in managing treatment-related Afib in patients receiving treatment with BTKi inhibitors? What insights do recent data provide?
- Kaiser RWD - Krackeler, et al. ASCO 2024. Abs 11158 @54:33 zanubrutinib go away over time. Less cardiac

What is the role of medications for anticoagulation and rhythm control? Dose reductions/holds?When do you involve cardiology?
When may alternative therapy be warranted and what is your approach in these scenarios?