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Hossein Borghaei, DO, associate professor at Fox Chase Cancer Center, discusses selecting between nivolumab (Opdivo) and pembrolizumab (Keytruda) in second-line non–small cell lung cancer (NSCLC).
Hossein Borghaei, DO, associate professor at Fox Chase Cancer Center, discusses selecting between nivolumab (Opdivo) and pembrolizumab
(Keytruda) in second-line non—small cell lung cancer (NSCLC).
There is no head-to-head comparison of 1 agent versus the other, said Borghaei, so all oncologists have to go on are the clinical data from separate clinical trials. It is always difficult to do cross-trial comparisons, he said.
Scheduling is a factor in decision making, as nivolumab is given every 2 weeks versus pembrolizumab which is given every three weeks.
From a clinical decision-making process, most patients who are now in second-line, as long as they have reasonable performance status and can withstand any potential toxicity that could arise, would be candidates for treatment with either of these agents, said Borghaei.
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