Women in families with MSH2 germline mutation for Lynch syndrome need to be counseled, especially if they test positive for the mutation, states Ginsburg. These women have a very high risk of uterine cancer and endometrial cancer. Additionally, the risk of uterine cancer in those families is higher than the risk of ovarian cancer.  

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Ophira M. Ginsburg, MSc, MD, FRCPC, director of the High Risk/Cancer Genetics Program at NYU Langone's Perlmutter Cancer Center, discusses determining which patients should receive genetic testing for gynecologic malignancies.

Dr. Ginsburg on Determining Genetic Testing in Gynecologic Malignancies