Arjun Balar, MD, director, Genitourinary Medical Oncology Progam, NYU Langone Medical Center, discusses the results from the KEYNOTE-052 trial in cisplatin-ineligible advanced urothelial carcinoma.

In this study of 370 patients, 200 mg of pembrolizumab (Keytruda) was administered every 3 weeks. At week 9, imaging was performed and then every 6 weeks for the first year and every 12 weeks beyond that.

The study met its primary end point of overall response rate, which was 27% among patients with a greater than 4-month follow-up. The complete response rate was 6%.

Balar concludes that this study confirms the effectiveness and durability of pembrolizumab in cisplatin-ineligible patients with urothelial carcinoma.

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The OncLive Genitourinary Cancer condition center page is a comprehensive resource for clinical news and expert insights across genitourinary (GU) malignancies, including renal cell carcinoma, urothelial carcinoma, and prostate cancer. This section features news articles, interviews in written and video format, and podcasts that focus on the evolving treatment paradigm of GU cancers and emerging research. 

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Genitourinary Cancers Symposium (ASCO GU)

Arjun Balar, MD, director, Genitourinary Medical Oncology Progam, NYU Langone Medical Center, discusses the results from the KEYNOTE-053 trial in cisplatin-ineligible advanced urothelial carcinoma.

Dr. Balar on Results of KEYNOTE-052 in Urothelial Cancer