Current Standards and Unmet needs in Advanced Gastric/GEJ Cancer

Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, review the current frontline standards of care for advanced gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma, emphasizing how modern immunotherapy-based regimens have reshaped treatment expectations. They highlight key gaps in care, including heterogeneous patient biology, limited durability of response, and the need for more precise biomarker-driven strategies. Janjigian and Wainberg also discuss patient- and disease-specific prognostic factors that influence outcomes and inform individualized treatment planning.