Emerging Treatment Approaches for HR+/HER2– Early-Stage Breast Cancer - Episode 5
Clinical Decision-Making for a Patient With eBC: Scenario and Strategies
Panelists discuss how differences in trial designs, including inclusion criteria, dosing, and end points, influence clinical decision-making in the use of CDK4/6 inhibitors for HR+/HER2– early breast cancer (eBC), with a focus on the NATALEE trial’s analysis of patients with no or low nodal involvement, and how recent expanded approval of ribociclib for high-risk node-positive and node-negative eBC patients guides the identification of ideal candidates based on clinical factors.
Video content above is prompted by the following:
- Please describe notable differences in the trial designs or analyses (eg, inclusion criteria, dosing, end points) with these CDK4/6 inhibitors in eBC.
- How do these differences impact your clinical decision-making?
- The latest NATALEE trial analysis (N0 subgroup) examines patients with no or low nodal involvement; can you please describe your experience with this patient population?
- With the recent expanded approval of ribociclib for node-positive and node-negative HR+/HER2– eBC patients with a high risk of recurrence, what patient characteristics or clinical factors make someone an ideal candidate for adjuvant ribociclib?
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