ASCO 2024: Immunotherapy for the Treatment of Small Cell Lung Cancer - Episode 3

cCRT-to-Durvalumab Interval in Limited Stage LS-SCLC

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Tarita O. Thomas, MD, PhD discusses patients with LS-SCLC, and what she would consider to be a reasonable time interval between completion of cCRT to initiation of consolidation therapy with a PD-L1 inhibitor. The panel also discusses the potential for curative-intent immunotherapy with durvalumab for earlier stages of SCLC.

  1. In patients with LS-SCLC, what would you consider to be a reasonable time interval between completion of cCRT to initiation of consolidation therapy with a PD-L1 inhibitor?
    1. Please discuss your thoughts on the range of time prior to initiating therapy - from immediately to 6 weeks post-cCRT.
  2. What is the potential for curative-intent immunotherapy with durvalumab for earlier stages of SCLC?
    1. What is the role of SBRT in earlier stages of disease vs cCRT followed by durvalumab?