Updates on HER2-Directed ADCs Across Solid Tumors - Episode 5
ADCs Targeting GI Cancers
Vijayakrishna Gadi, MD, University of Illinois College of Medicine, Susana Campos, MD, MPH, Matthew D. Galsky, MD, Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA, Aparna R. Parikh, MD Dr Parikh discusses the history of ADCs for treating GI cancers with a focus on the data for T-DXd and its role in treating these cancers.
Video content above is prompted by the following:
- Please review the data for T-DM1 for:
- HER2+ advanced or metastatic gastric or gastroesophageal junction (GEJ) adenocaricoma: GATSBY; Shah-Gastric Cancer_2019: Biomarker analysis of GATSBY
- T-DM1 + Pertuzumab for HER2-amplified colorectal cancer: HERACLES-B trial
- Please review the data for T-DXd for:
- HER2+ gastric or GEJ: DESTINY-Gastric01; Shitara_Nature Med_2024: Biomarker Analysis of DESTINY-Gastric01 and DESTINY-Gastric02
- Unresectable or metastatic HER2+ CRC: DESTINY-CRC01 1. DESTINY-CRC02 – Raghav_ASCO 2023
- HER2+ and HER2-low GC: DESTINY-Gastric03 Janjigian ASCO 2024
- Retrospective Cohort Study EN-DEAVOR: Nakanishi ASCO 2024
- What is the potential for HER2-targeting ADCs in other GI cancers?
- Biliary Tract Cancers, Pancreatic
- PanTumor02: Meric-Bernstam_J Clin Oncol_2024; a. BTC and PC Cohort Outcomes: Oh ASCO 2024 #4090
- HERB trial (BTC): Ohba_ASCO2022
- Where do HER2-directed ADCs fit into the treatment armamentarium for GI cancers?
- Is there an unmet need ADCs could help fill?