Multiple Myeloma | Specialty

The OncLive Multiple Myeloma condition center page is a comprehensive resource for clinical news and expert insights on multiple myeloma and how to treat patients with monoclonal antibodies, proteasome inhibitors, bispecific T-cell engagers, immunomodulatory agents, CAR T-cell therapy, and more. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in multiple myeloma.

Belantamab Mafodotin Dosing Strategies in Patients with RRMM

March 14th 2022

What to know in terms of dosing belantamab mafodotin treatment in patients with relapsed/refractory multiple myeloma.

Selecting Appropriate Treatment for Patients With Heavily Pretreated Multiple Myeloma

March 14th 2022

Variables that impact treatment decisions for relapsed/refractory multiple myeloma.

Unmet Needs in the Management of Multiple Myeloma

March 11th 2022

Sagar Lonial, MD, provides insight on mechanisms of resistance to CAR T-cell therapies, and the panel shares unmet needs and future directions for the treatment of multiple myeloma.

Role of CAR T Therapies in Newly Diagnosed Multiple Myeloma

March 11th 2022

Ola Landgren, MD, PhD, leads the discussion on the use of cilta-cel and ide-cel in newly diagnosed multiple myeloma and the sequencing of available therapies in transplant-eligible and transplant-ineligible patients.

Novel CAR-T Therapies in Relapsed/Refractory MM and Identifying the Right Patients for CAR-T Therapies

March 11th 2022

Experts discuss emerging BCMA-targeting CAR T-cell therapies under investigation for treating multiple myeloma and barriers to CAR T access.

Charting a Path for the Integration of Immunotherapy in the Treatment of Multiple Myeloma

March 11th 2022

Fenghuang Zhan, MD, PhD, and John D. Shaughnessy, Jr, PhD, discuss the need for a paradigm shift in the treatment of multiple myeloma with the integration of immunotherapy.

Dr. Larocca on What to Know when Diagnosing Difficult-to-Treat Patients in Multiple Myeloma

March 8th 2022

Alessandra Larocca, MD, PhD, discusses what to know when diagnosing difficult-to-treat patients with multiple myeloma.

Management of a 61-Year-Old Female With Heavily Pretreated RRMM

March 8th 2022

Natalie Callander, MD, presents the profile of a female patient with relapsed/refractory multiple myeloma who receives belantamab mafodotin and develops keratopathy.

Safety of Belantamab Mafodotin in Patients With RRMM

March 8th 2022

Karen L. Klugo, MD, describes what’s unique in terms of patient response to belantamab mafodotin as treatment for relapsed/refractory multiple myeloma and risk of ocular disease.

Inside the Clinic: JTCC Experts Highlight Key Takeaways from ASH 2021

March 7th 2022

David Siegel, MD, PhD, Noa Biran, MD, and David H. Vesole, MD, PhD, discuss key takeaways from ASH 2021.

Part 1 Results of Belantamab Mafodotin in Combination with Pomalidomide and Dexamethasone for RRMM

March 7th 2022

Sagar Lonial, MD, discusses the part 1 results of a study combining belantamab mafodotin with pomalidomide and dexamethasone when treating relapsed/refractory multiple myeloma, as presented by Suzanne Trudel, MD, at the American Society of Hematology 2021 Annual Meeting.

FDA Approval of Cilta-Cel Fast Tracks Multiple Myeloma Toward Curative Potential

March 7th 2022

Sundar Jagannath, MBBS, discusses the significance of the FDA approval of ciltacabtagene autoleucel, important adverse effects to be aware of, and shared his thoughts on where the treatment fits into the current and future treatment paradigms.

KarMMa Study in Relapsed/Refractory Multiple Myeloma

March 4th 2022

Katja Weisel, MD, reviews the study results from the KarMMa study evaluating the use of ide-cel in patients with relapsed/refractory multiple myeloma.

CARTITUDE-1 Study in Relapsed/Refractory Multiple Myeloma

March 4th 2022

Ola Landgren, MD, PhD, leads a review of the updated efficacy and safety results and subgroup analysis of the CARTITUDE-1 study for patients with relapsed/refractory multiple myeloma.

Dr. Jagannath on the FDA Approval of Cilta-Cel in Relapsed/Refractory Multiple Myeloma

March 3rd 2022

Sundar Jagannath, MBBS, discusses the FDA approval of ciltacabtagene autoleucel in relapsed/refractory multiple myeloma.

FDA Grants Fast Track Status to HPN217 for Relapsed/Refractory Multiple Myeloma

March 3rd 2022

The FDA has granted a to the BCMA-targeting Tri-specific T-cell Activating Construct, HPN217, for use as a potential therapeutic option in patients with relapsed or refractory multiple myeloma who have previously received at least 4 lines of therapy.

Bispecific Antibodies Show Potential After Relapse on CAR T-cell Therapy in Myeloma

March 2nd 2022

Oliver Van Oekelen, MD, MSc, discusses findings from a retrospective study that evaluated treatment and efficacy outcomes in patients with relapsed or refractory multiple myeloma who experienced disease progression after BCMA-directed CAR T-cell therapy.

Talquetamab/Daratumumab Shows Promise in Heavily Pretreated Myeloma, Warranting Further Investigation

March 1st 2022

Ajai Chari, MD, discusses the safety and efficacy of talquetamab plus daratumumab in heavily pretreated patients with multiple myeloma, initial data from phase 1b TRIMM-2 trial, and the potential to move the combination into earlier lines of therapy.

FDA Approves Cilta-Cel for Relapsed/Refractory Multiple Myeloma

March 1st 2022

The FDA has approved ciltacabtagene autoleucel for the treatment of adult patients with relapsed and/or refractory multiple myeloma following 4 or more prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.

Clinical Case 3: A 56-Year-Old Man With Multiple Myeloma

February 25th 2022

Expert hematologist-oncologists review the case of a 56-year-old man with multiple myeloma who received CAR T-cell therapy and share their approaches to treatment.