Multiple Myeloma | Specialty

The OncLive Multiple Myeloma condition center page is a comprehensive resource for clinical news and expert insights on multiple myeloma and how to treat patients with monoclonal antibodies, proteasome inhibitors, bispecific T-cell engagers, immunomodulatory agents, CAR T-cell therapy, and more. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in multiple myeloma.

FDA Approves Elranatamab for Relapsed or Refractory Multiple Myeloma

August 14th 2023

The FDA has granted accelerated approval to elranatamab-bcmm (Elrexfio) for the treatment of adult patients with relapsed or refractory multiple myeloma who have previously received at least 4 lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.

Teclistamab Plus Nirogacestat Elicits Durable Responses in Relapsed/Refractory Myeloma

August 11th 2023

The combination of teclistamab and nirogacestat produced high and deep responses in patients with relapsed/refractory multiple myeloma.

Linvoseltamab Produces Durable Responses in Relapsed/Refractory Multiple Myeloma

August 10th 2023

Hans Lee, MD, discusses unmet needs in patients with relapsed/refractory multiple myeloma, highlights key efficacy and safety findings from the LINKER-MM1 trial, and how these data may inform the future of the multiple myeloma treatment paradigm.

FDA Approves Talquetamab for Relapsed/Refractory Multiple Myeloma

August 10th 2023

The FDA has granted accelerated approval to talquetamab-tgvs for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least 4 prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 antibody.

Dr Patel on the Background of the KarMMa-3 Trial in Relapsed/Refractory Multiple Myeloma

August 8th 2023

Krina K. Patel, MD, MSc, discusses the background of the phase 3 KarMMa-3 trial, which investigated idecabtagene vicleucel in patients with high-risk, relapsed/refractory multiple myeloma.

Multiple Myeloma: Unmet Needs and Future Directions in Care

August 8th 2023

After discussing earlier-line use of CAR T-cell therapy in patients with multiple myeloma, the panel considers key takeaways and future evolutions in the treatment landscape.

CAR T-Cell Therapy in Multiple Myeloma: Updates from ASCO 2023 and Beyond

August 8th 2023

Before closing out their discussion on novel therapies in multiply relapsed multiple myeloma, panelists identify the evolving role of CAR T-cell therapy.

Dr Mohty on the Promise of Elranatamab in Relapsed/Refractory Multiple Myeloma

August 3rd 2023

Mohamad Mohty, MD, PhD, discusses the promise of the phase 2 MagnetisMM-3 trial in patients with relapsed/refractory multiple myeloma, which is investigating elranatamab monotherapy in this patient population.

Talquetamab Produces Durable Responses in Relapsed/Refractory Multiple Myeloma

August 2nd 2023

Carolina D. Schinke, MD, discusses key efficacy findings from the MonumenTAL-1 trial, adverse effects to be aware of with talquetamab, and what the findings from this trial reveal about the potential future for talquetamab and other bispecific antibodies in patients with multiple myeloma.

Dr Costa on the Background of the MASTER Trial in Newly Diagnosed Multiple Myeloma

August 1st 2023

Luciano J. Costa, MD, PhD, discusses the background of the phase 2 MASTER trial in newly diagnosed multiple myeloma.

Combination Strategies With Bispecifics in Multiple Myeloma

August 1st 2023

Key opinion leaders on multiple myeloma reflect on the use of combination strategies with bispecifics in the multiply relapsed setting.

Bispecifics in Multiple Myeloma: Adverse Event Management

August 1st 2023

Expert perspectives on adverse event management in patients on bispecific therapy for multiply relapsed multiple myeloma.

Dr Mohty on Bispecific Antibodies in R/R Multiple Myeloma

July 28th 2023

Mohamad Mohty, MD, PhD, discusses unmet needs in patients with relapsed/refractory multiple myeloma and the rationale for investigating elranatamab monotherapy in this population in the phase 2 MagnetisMM-3 trial.

Dr Bal on Sequencing Considerations for BMCA- and GPRC5D-Targeted Agents in Multiple Myeloma

July 27th 2023

Susan Bal, MD, discusses questions remaining regarding sequencing of treatments in later lines for patients with relapsed/refractory multiple myeloma.

FDA Clears Investigational New Drug Application for TCR-NK Cell Therapy in Multiple Myeloma

July 26th 2023

The FDA has issued a ‘safe to proceed’ for the investigational new drug application enabling a phase 1 study evaluating NY-ESO-1 TCR/IL-15 NK, a first-in-class engineered T-cell receptor natural killer cell therapy for patients with relapsed/refractory multiple myeloma.

Dr Matous on the Future Directions of CAR T-Cell Therapy in Multiple Myeloma

July 25th 2023

Jeffrey V. Matous, MD, discusses future directions of CAR T-cell therapy in multiple myeloma, highlighting the potential promise of novel targets beyond BCMA.

Bispecifics in Multiple Myeloma: Dosing and Transition of Care

July 25th 2023

A brief review of logistical considerations that play a part in selecting novel therapy for patients with multiply relapsed multiple myeloma.

Multiple Myeloma: Sequencing Novel Therapies in Later Lines of Treatment

July 25th 2023

Focused discussion on the sequencing of bispecifics or CAR T-cell therapies in patients with multiply relapsed multiple myeloma.

Dr Munshi on the Background of the CARTITUDE-1 Trial in Multiple Myeloma

July 24th 2023

Nikhil C. Munshi, MD, discusses the background of the phase 1b/2 CARTITUDE-1 trial of ciltacabtagene autoleucel in patients with relapsed/refractory multiple myeloma and highlights the specific patient population enrolled in the study.

Dr Patel on Safety Data and Biomarker Outcomes With Ide-Cel in High-Risk R/R Multiple Myeloma

July 21st 2023

Krina K. Patel, MD, MSc, discusses the safety profile of idecabtagene vicleucel in a subgroup of patients with high-risk, relapsed/refractory multiple myeloma, as well as findings with soluble BCMA levels from the phase 3 KarMMa-3 trial.