Thomas C. Krivak, MD

The NRG-GY018 Trial: Pembrolizumab Plus Chemotherapy in Advanced Endometrial Cancer

December 6th 2023

Dr Thomas C. Krivak highlights key data from the GY018 trial investigating chemotherapy plus pembrolizumab in both dMMR and pMMR advanced endometrial cancer, confirming and extending the findings from the RUBY trial supporting pembrolizumab's approval and use in both dMMR and pMMR populations.

Dostarlimab Plus Carboplatin and Paclitaxel for Advanced or Recurrent Endometrial Cancer: Data from the RUBY Trial

December 6th 2023

Thomas C. Krivak, MD, shares the positive results from the RUBY trial of pembrolizumab plus chemotherapy followed by maintenance in patients with dMMR advanced endometrial cancer, supporting its approval and use in this population.

The Role of dMMR in the Progression of Endometrial Cancer

November 29th 2023

David M. O’Malley, MD, details the definition of dMMR (mismatch repair deficiency), its prevalence in advanced endometrial cancer, and current treatment approaches for dMMR patients, with a focus on the potential for cure in recurrent/metastatic dMMR patients based on clinical trial data.

Shared Decision-Making in Advanced or Recurrent Endometrial Cancer

November 29th 2023

The panel discusses factors to consider when determining best treatment options for patients with recurrent or advanced endometrial cancer, including traditional clinical trial endpoints, cost, chance for cure versus disease control, and most importantly, patient preference.

Updated NCCN Guidelines for the Treatment of Advanced or Recurrent Endometrial Cancer

November 22nd 2023

Key opinion leaders review recent updates to the NCCN guidelines for treating recurrent and advanced endometrial cancer, including biomarker testing and targeted therapies like dostarlimab and trastuzumab.

Diagnosing and Staging Patients With Endometrial Cancer

November 22nd 2023

Expert gynecologic oncologists discuss recent progress in treating advanced endometrial and cervical cancers, including epidemiology, risk factors, evaluation, staging, and molecular testing.

HRD Testing in Ovarian Cancer: Clinical Guidelines Recommendations

August 2nd 2023

Panelists discuss clinical guidelines recommendations for HRD testing in ovarian cancer and how they inform their practice.

Leveraging HRD Testing Results in Ovarian Cancer: Clinical Data

August 2nd 2023

Discussion centered around data from the PAOLA-1 trial, highlighting the prevalence of BRCA1/2 mutations and HRD status in ovarian cancer, and how patients with these alterations may benefit from PARP inhibitor treatment.

Commercially Available 
HRD Tests for Ovarian Cancer

July 27th 2023

The panel reviews commercially available HRD tests and expand upon factors that may influence test choice, such as clinical performance, institutional availability, turnaround time, and cost.

Other Causes of HRD: Chromosomal LOH, LST, and TAI

July 27th 2023

Dr Hagemann explains how loss of heterozygosity (LOH), large-scale state transitions (LSTs), and telomeric allelic imbalance (TAI) can also contribute to HRD.

Defining HRD and its Role in Ovarian Cancer

July 20th 2023

Experienced clinicians explain the role of the homologous recombination repair (HRR) pathway in DNA repair and how mutations in HRR-related genes, including BRCA1 and BRCA2, can cause homologous recombination deficiency (HRD) and contribute to the development and progression of ovarian cancer (OC).

Opening Remarks from Dr. Herzog, Dr. Krivak, and Dr. Hagemann

July 20th 2023

Thomas Herzog, MD, Thomas Krivak, MD, and Ian Hagemann, MD, PhD open their discussion by introducing themselves and the objectives of the program.

Dr. Krivak on the Importance of Germline Genetic Testing in Ovarian Cancer

March 1st 2021

Thomas C. Krivak, MD, discusses the importance of germline genetic testing in ovarian cancer.

Systemic Management of Ovarian Cancer: Closing Thoughts

May 27th 2020

Novel Combination Strategies in Recurrent Ovarian Cancer

May 27th 2020

Recurrent Ovarian Cancer: Novel Agents Under Investigation

May 27th 2020

Bevacizumab’s Role in Recurrent Ovarian Cancer

May 27th 2020

Recurrent Ovarian Cancer: Choosing a PARP Inhibitor

May 27th 2020

PARP Inhibition’s Role in Recurrent Ovarian Cancer

May 27th 2020

Frontline Ovarian Cancer Management: Ongoing Clinical Trials

May 27th 2020