Kelly E. McCann, MD, PhD

Kelly E. McCann, MD, PhD, is an assistant professor and breast medical oncologist at UCLA.

Articles

TROPiCS-02 Trial: Sacituzumab Govitecan in HR+/HER2– Breast Cancer

July 7th 2025

Panelists discuss how the TROPiCS-02 trial established sacituzumab govitecan for hormone receptor–positive, HER2-negative metastatic breast cancer and how it influences sequencing decisions with other antibody-drug conjugates (ADCs) such as trastuzumab deruxtecan.

When to Introduce ADCs in HR+/HER2– mBC

June 30th 2025

Panelists discuss how they decide when to transition from endocrine-based therapies to antibody-drug conjugates, considering factors such as endocrine sensitivity, disease burden, and pace of progression.

Optimizing Treatment Selection and Sequencing in HR+/HER2– mBC

June 30th 2025

Panelists discuss how to approach decision-making among PI3K/AKT pathway inhibitors (capivasertib, alpelisib, everolimus) based on mutation status, toxicity profiles, and dosing schedules in the second-line setting.

Dr McCann on the Importance of Reaching Consensus on the Role of Vepdegestrant in ER+ Breast Cancer

June 25th 2025

Kelly McCann, MD, PhD, discusses the need to reach consensus on the potential role of vepdegestrant for ER-positive, HER2-negative advanced breast cancer.

Efficacy and Safety of Next-Generation Oral SERDs for HR+/HER2– mBC

June 23rd 2025

Panelists discuss how upcoming oral selective estrogen receptor degraders (SERDs; eg, camasertinib, imlunestrant, and giredestrant) are showing efficacy primarily in populations with ESR1 mutations and are all well-tolerated oral agents that will likely receive approvals.

The Role of Elacestrant in the Treatment of ER+/HER2– mBC

June 23rd 2025

Panelists discuss how elacestrant from the EMERALD trial is being incorporated into practice based on ESR1 mutation status and duration of prior CDK4/6 inhibitor therapy, with combination approaches being explored in the ELEVATE trial.

Camizestrant in HR+/HER2– mBC: Emerging Data From the SERENA-6 Trial

June 16th 2025

Panelists discuss how the SERENA-6 trial design uses circulating tumor DNA (ctDNA) monitoring to detect ESR1 mutations and switch patients from aromatase inhibitors to oral selective estrogen receptor degraders (SERDs) such as camasertinib while continuing CDK4/6 inhibitors.

Biomarker Testing Strategies in Metastatic Breast Cancer

June 16th 2025

Panelists discuss how they will review the latest updates in hormone receptor–positive, HER2-negative, and HER2-low metastatic breast cancer, focusing on oral selective estrogen receptor degraders (SERDs), targeted therapies, and antibody-drug conjugates presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting.

Looking to the Future: Emerging Therapeutic Approaches in HER2+ Breast Cancer

June 4th 2025

Panelists discuss how emerging developments in HER2-positive (HER2+) breast cancer treatment, including novel antibody-drug conjugates, bispecific antibodies, and cytotoxic-sparing regimens for hormone receptor+ (HR+)/HER2+ disease, are creating exciting new options for patients.

Clinical Insights Into Managing Heavily Pretreated HER2+ Metastatic Breast Cancer

May 28th 2025

Panelists discuss how they approach treatment beyond third-line therapy for HER2-positive (HER2+) metastatic breast cancer, considering factors such as prior therapies, residual toxicities, and patient preferences when selecting from multiple options.

Balancing Efficacy and Tolerability: Expert Insights Into Tucatinib Triplet Therapy for HER2+ Breast Cancer

May 28th 2025

Panelists discuss how they manage adverse effects of tucatinib-based therapy, particularly focusing on diarrhea and palmar-plantar erythrodysesthesia from capecitabine, with practical dosing strategies to improve tolerability.

Dr McCann on the Biologic Heterogeneity Within HER2+ Breast Cancer

May 26th 2025

Kelly E. McCann, MD, PhD, discusses the biologic heterogeneity within HER2-positive breast cancer and highlights the clinical implications of HR status in this disease subset.

Patient-Centered Decisions and Evolving Treatment Landscape for HER2+ Metastatic Breast Cancer

May 23rd 2025

Panelists discuss how treatment decisions in later-line settings should incorporate clinical trials, patient preferences regarding quality of life, medication scheduling, financial considerations, and previous adverse effect experiences, while also addressing special considerations for brain metastases.

Tucatinib Combinations in HER2+ Breast Cancer: HER2CLIMB-02 and HER2CLIMB-05

May 21st 2025

Panelists discuss how the HER2CLIMB-02 and HER2CLIMB-05 trials might impact treatment sequencing, with particular interest in using tucatinib earlier in treatment to potentially prevent brain metastases.

Navigating Third-Line Treatment Options in HER2+ Breast Cancer: ADC or TKI

May 21st 2025

Panelists discuss how National Comprehensive Cancer Network (NCCN) guidelines inform third-line treatment options for HER2-positive (HER2+) metastatic breast cancer, with particular focus on the HER2CLIMB regimen (tucatinib, capecitabine, and trastuzumab) for patients with brain metastases.

Navigating the Data: Later-Line Systemic Therapies for HER2+ Metastatic Breast Cancer

May 16th 2025

Panelists discuss how fourth-line treatment options include margetuximab (which interacts better with the immune system), neratinib-capecitabine (an irreversible pan-HER inhibitor), and antibody-drug conjugates (ADCs) with different payloads, though toxicity profiles must be considered.

Expert Insights on Third-Line Treatment Decisions for HER2+ Metastatic Breast Cancer

May 16th 2025

Panelists discuss how third-line treatment options after T-DXd progression include T-DM1 and the HER2CLIMB regimen (tucatinib-capecitabine-trastuzumab), with consideration of brain metastases as a key factor in treatment selection.

Clinical Insights on the Next Treatment Approach for Metastatic HER2+ Breast Cancer with Brain Metastasis

May 14th 2025

Panelists discuss how they would approach multiple brain metastases at initial metastatic diagnosis, debating the use of stereotactic radiosurgery vs systemic therapy with agents that cross the blood-brain barrier.

Forty-Seven-Year-Old Woman With Recurrent HER2+ Breast Cancer and Brain Metastases

May 14th 2025

Panelists discuss how they approach the case of a 47-year-old marketing executive with initially low-risk HER2-positive (HER2+) breast cancer who developed brain, liver, lung, and bone metastases shortly after completing adjuvant therapy.

Navigating Early-Line Treatment Options for HER2+ Metastatic Breast Cancer

May 9th 2025

Panelists discuss how the treatment landscape for early HER2-positive metastatic breast cancer has evolved, with taxane-pertuzumab-trastuzumab as first-line standard of care and T-DXd supplanting T-DM1 as the preferred second-line treatment.