Dana-Farber Cancer Institute

Articles

Research Uncovers Alternate Mechanism for Producing Key Protein in Metastatic Prostate Cancer

April 17th 2023

In a new study in the journal Nature Cancer, Dana-Farber Cancer Institute scientists shed new light on the mechanism that raises and lowers PSMA expression in prostate cancer cells.

Sox9 Protein Enables Molecular Time Travel That Can Lead to Colorectal Cancer

April 5th 2023

Research from Dana-Farber Cancer Institute looks at what happens before the emergence of mutations that interrupt cellular differentiation in colorectal cancer and finds not only evidence of fetal reprogramming that can initiate cancer, but also a protein, Sox9, that fuels that reprogramming.

Novobiocin Attacks BRCA-Mutated Cancer Cells from Within and Without, Study Shows

March 31st 2023

As the first clinical trial of the drug novobiocin is about to open for patients with cancers carrying BRCA gene mutations, new research at Dana-Farber Cancer Institute shows the drug poses a double threat to tumor cells.

Dana-Farber Researchers Chart a Course for Understanding, Preventing, and Treating Young-onset Colorectal Cancer

March 29th 2023

Dana-Farber Cancer Institute researchers outline the complexities of colorectal cancer and the research needed to map out a path toward understanding it.

Dana-Farber Research Supports FDA Approval of New Therapy for Metastatic Breast Cancer

February 16th 2023

Sacituzumab govitecan, a novel antibody drug-conjugate therapy has been granted accelerated approved by the U.S. Food and Drug Administration for the treatment of metastatic HR+, HER2- breast cancer.

Results of the SORAYA Study Show Conjugate Therapy Produced Remissions in One-third of Patients With Drug-Resistant Ovarian Cancer

February 10th 2023

In an internationally conducted clinical trial lead by Dana-Farber involving patients with recurrent ovarian cancer that is resistant to platinum therapy, a novel conjugate therapy called mirvetuximab soravtansine resulted in substantially better responses than standard treatments.

Three-Drug Combination Therapy Effective in Patients with High-Risk CLL, Trial Shows

February 1st 2023

A three-drug combination that sent chronic lymphocytic leukemia into deep remissions in a broad group of patients in a clinical trial is highly effective in patients with high-risk forms of the disease, a new, phase 2 clinical trial led by Dana-Farber Cancer Institute investigators indicates.

Study Finds That Risk of Adverse Effects From Cancer Immunotherapy is Higher in Patients With Certain Inherited Genetic Variations

January 30th 2023

In a new study, scientists at Dana-Farber Cancer Institute identify, for the first time, inherited genetic variations that place patients at high risk for these complications.

CAR-T-cell Shows Promise in Patients With Lymphoma of the Brain and Spinal Cord in Early Trial

January 24th 2023

A CAR-T-cell therapy known as axicabtagene ciloleucel is safe and shows encouraging signs of efficacy in a small pilot trial involving patients with lymphoma of the brain and/or spinal cord.

Paper Proposes New Community-Oriented Fellowship Training Model for Hematologists/Oncologists

December 22nd 2022

As patients with cancer increasingly receive treatment in community hospitals and clinics and many such centers experience a shortage of oncologists, a group of physicians at Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, and Harvard Medical School has proposed the first-ever training blueprint for oncologists planning careers in a community or academic-community setting.

Scientists Map Genetic Evolution of Chronic Lymphocytic Leukemia to Richter Syndrome

December 21st 2022

In a new study, scientists reveal for the first time the genomic differences between chronic lymphocytic leukemia and Richter's, the molecular pathways by which Richter's emerges, and the existence of multiple subtypes of the disease.

New Clinical Tool for Clonal Hematopoiesis Identifies Patients at High Risk for Blood Cancer

December 14th 2022

A new clinical tool developed by a team of researchers led by the Dana-Farber Cancer Institute pinpoints which clonal hematopoiesis patients are at highest risk for cancer progression.

Dana-Farber Researchers to Present Findings at San Antonio Breast Cancer Symposium

December 6th 2022

Researchers from Dana-Farber Cancer Institute will present more than 30 research studies at the 44th annual San Antonio Breast Cancer Symposium on December 7-10th.

Study Shows That Immune System Holds Clues To Patients With High-risk Smoldering Myeloma Likely To Benefit From Treatment

December 1st 2022

In a new study, investigators at Dana-Farber Cancer Institute demonstrate that changes in immune system cells can indicate which patients with high-risk "smoldering" myeloma are likely to progress to myeloma and which will benefit the most from treatment.

Dana-Farber Research Supports FDA Approval of New Therapy for Certain Patients With Ovarian Cancer

November 23rd 2022

Mirvetuximab soravtansine has been granted accelerated approval by the U.S. Food and Drug Administration on November 14 for the treatment of recurrent platinum-resistant high-grade serous ovarian cancer that highly expresses folate receptor alpha.

Computer Platform Helps Match Patients With Cancer to Trials of Targeted Therapy

October 14th 2022

A computer platform developed at Dana-Farber Cancer Institute makes the matching process for clinical trials for patients with genomic alterations both easier and faster.

Dana-Farber Joins Parker Institute for Cancer Immunotherapy to Accelerate Cures for the World’s Gravest Cancers

October 4th 2022

Dana-Farber Cancer Institute, one of the world’s leading cancer research and treatment centers, has partnered with the Parker Institute for Cancer Immunotherapy, the leading network of immuno-oncology expertise in the world, as a member of the PICI Network with a goal to better understand the tumor microenvironment across cancer types and translate these basic discoveries to the clinic as impactful cancer immunotherapies.

Online Testing Tool Identifies People Likely to Benefit from Genetic Testing for Inherited Risk for Certain Cancers

August 23rd 2022

An online tool developed by researchers and physicians at Dana-Farber Cancer Institute can accurately and rapidly identify people who should undergo testing for inherited genetic changes that raise the risk of developing certain cancers, a new study shows.

Dana-Farber Brigham Cancer Center Opens New Facility in Foxborough

August 18th 2022

Dana-Farber Brigham Cancer Center opened a new facility in Foxborough, MA, which provides world-class cancer care to patients in southern Massachusetts and Rhode Island.

Dana-Farber Cancer Institute and Lifespan Renew Strategic Alliance Agreement

May 2nd 2022

Dana-Farber Cancer Institute and the Lifespan Cancer Institute have agreed to renew their strategic alliance to advance cancer treatment and research. Dana-Farber and the Lifespan Cancer Institute signed an initial agreement in 2017.