Teclistamab-Based Induction Is Effective and Generates MRD Negativity in Newly Diagnosed Myeloma: With Marc S. Raab, MD

Welcome to OncLive On Air®! I'm your host today, Jax DiEugenio.

OncLive On Air® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we had the pleasure of speaking with Marc S. Raab, MD, about the post-induction outcomes and updated minimal residual disease (MRD) analyses from the phase 2 MajesTEC-5 study (NCT05695508), which is evaluating teclistamab-cqyv (Tecvayli)–based induction regimens in patients with newly diagnosed multiple myeloma. Dr Raab is a professor of medicine at Heidelberg University in Germany.

In our exclusive interview, Dr Raab discussed the rationale for integrating bispecific antibodies in the frontline multiple myeloma setting, the depth and durability of responses observed following teclistamab-based induction, and the implications of MRD findings for treatment sequencing and potential transplant strategies. He also highlighted key safety considerations, the role of step-up dosing, and how these data may shape evolving approaches to early T-cell–redirecting therapy in newly diagnosed disease.

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