Next Steps With Obesity-Related Genes in Patients With RCC

Julia R. Mendoza-Perez, PhD, visiting scientist, Epidemiology, The University of Texas MD Anderson Cancer Center, discusses next steps and research regarding obesity-related genes in patients with renal cell carcinoma (RCC).

In a study, researchers found that LEPR methylation is associated with kidney cancer tumorgenesis and that LEPR methylation levels were found to be significantly high in tumor tissue versus normal tissue. Additionally, these methylation levels are also associated with recurrence risk for kidney cancer as well as the clinical feature of the disease.

In the future, using this study’s tissue samples can help gain a deeper understanding of a tumor’s behavior and microenvironment, Mendoza-Perez explains. Additionally, she hopes that next steps will entail more research on molecular mechanisms, as there are several unanswered questions following the study’s findings.

In conclusion, Mendoza-Perez hopes to prevent disease recurrence with this research.