Johnson Previews the Potential Utility of VS-6766 Plus Defactinib in KRAS+ NSCLC

Welcome to OncLive On Air^®! I’m your host today, Caroline Seymour.

OncLive On Air^® is a podcast from OncLive^®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive^® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, sponsored by Verastem Oncology, we had the pleasure of speaking with Melissa Johnson, MD, program director of Lung Cancer Research at Sarah Cannon Research Institute, to discuss the potential utility of the combination of VS-6766 and defactinib in recurrent, KRAS-mutant non–small cell lung cancer (NSCLC).

The combination of the oral small molecule RAF/MEK inhibitor VS-6766 and the FAK inhibitor defactinib is currently under study in the phase 2 RAMP-202 trial (NCT04620330) in patients with recurrent, KRAS-mutant NSCLC.

In the phase 2 trial, investigators will evaluate the safety and efficacy of VS-6766 as a monotherapy and in combination with defactinib in patients with recurrent KRAS-mutant NSCLC.

In our exclusive interview, Johnson discussed the mechanism of action of VS-6766 alone and in combination with defactinib, expectations for the ongoing phase 2 RAMP 202 trial in KRAS-mutant NSCLC, and where the combination could be used in practice pending further positive study results.

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