FDA Approval Insights: Sotorasib Plus Panitumumab for KRAS G12C–Mutated mCRC: With Marwan Fakih, MD

Welcome to OncLive On Air®! I’m your host today, Jax DiEugenio.

OncLive On Air is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we had the pleasure of speaking with Marwan G. Fakih, MD, about the FDA approval of sotorasib (Lumakras) plus panitumumab (Vectibix) for the treatment of adult patients with KRAS G12C–mutated metastatic colorectal cancer (mCRC) who have previously been treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. Dr Fakih is a professor in the Department of Medical Oncology & Therapeutics Research, the associate director for Clinical Sciences, the medical director of the Briskin Center for Clinical Research, the division chief of GI Medical Oncology, and the co-director of the Gastrointestinal Cancer Program at City of Hope in Duarte, California.

In our exclusive interview, Dr Fakih discussed the significance of this approval, key findings from the pivotal CodeBreaK 300 trial (NCT05198934), and how this combination fits into the current KRAS G12C–mutated mCRC treatment paradigm.

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